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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Ezh2-mediated epigenetic modification is required for allogeneic T cell-induced lupus disease

Fig. 4

T cell Ezh2 deficiency suppresses T cell-dependent, but not T-independent Ab responses. a. Mice were injected with 200 μg of LPS i.p. at day 0. Serum levels of anti-dsDNA were detected by ELISA as in Fig. 1. b CD4.Ezh2-KO and B6.WT mice (n = 5) were injected i.p. with 300 μl of OVA adsorbed to alum. Sera were collected on day 14 and serum levels of isotypes of anti-OVA antibody were measured by ELISA. Solid triangle, WT-control group, untreated; solid square, WT group, OVA-treated; open circle, CD4.Ezh2-KO group, OVA-treated

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