Cerebral microvascular and microstructural integrity is regionally altered in patients with systemic lupus erythematosus

Table 2 Voxel cluster characteristics (cluster-level p < 0.05 family-wise error corrected)

IVIM parameter	Contrast	Peak location [x, y, z] mm	T-score threshold*	Cluster size [voxels]	Anatomic regions
v_bw	SLE < HC	[8, − 82, 50]	2.0	476	Right sup. parietal, mid. occipital, bilateral sup. occipital, precuneus, cuneus, calcarine, lingual, mid. cingulate
D^∗	SLE > HC	[− 7, − 56, 25]	2.0	629	Bilateral sup. parietal, mid. occipital, sup. occipital, angular, precuneus, cuneus, mid. cingulate, post. cingulate, calcarine, lingual
D	SLE > HC	[38, − 52, 55]	1.8	731	Right postcentral, sup. parietal, inf. parietal, angular, supramarginal, bilateral precuneus, cuneus
D^∗ × v_bw	SLE > HC	[− 52, − 86, − 5]	1.7	365	Left sup. parietal, inf. occipital, mid. occipital, sup. occipital, angular, lingual, bilateral precuneus, post. cingulate, calcarine
Intersection	–	–	–	29	Left cuneus, post. cingulate, bilateral precuneus

v_bw = blood volume fraction, D^∗ = effective diffusion coefficient, D = parenchymal diffusion coefficient, D^∗ × v_bw = flow parameter, Intersection = region common to all IVIM parameter clusters
*Nominal voxel threshold used to generate significant cluster

ISSN: 1478-6362