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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Methotrexate-loaded multifunctional nanoparticles with near-infrared irradiation for the treatment of rheumatoid arthritis

Fig. 4

Comparative studies of therapeutic efficacy in CIA mice. a The schedule for CIA induction and treatment. b Severity of arthritis in CIA mice. NC, negative control; G1, PBS-treated; G2, 35 mg/kg MTX solution twice per week intraperitoneal; G3, 0.2 mg/kg MTX solution once IV; G4, MTX-unloaded MNPs IV + NIR irradiation; G5, MTX-loaded MNPs IV; G6, MTX-loaded MNPs IV + NIR irradiation. Mean clinical scores were significantly decreased in G2 and G6 mice compared with untreated mice. c Changes in anti-collagen II IgG titers in mice of different treatment groups. Data are expressed as mean ± SEM of 5 mice for duplicated serum samples. **P < 0.01, ***P < 0.001 vs. the untreated group (G1)

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Arthritis Research & Therapy

ISSN: 1478-6362

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