Fig. 5

MTX-loaded MNPs with NIR irradiation ameliorate histopathologic changes and suppress pro-inflammatory cytokines in CIA mice. a Histological findings of ankle joints, original magnifications × 100. b, bone; c, cartilage; b, bone erosion; ic, inflammatory cell infiltration; sp, synovial proliferation. b Semiquantitative analyses of histological changes, *P < 0.01 vs. the untreated group (G1). c Cytokine assays by ELISA. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the untreated group (G1). Values are expressed as mean ± SEM of five mice