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Table 1 Treatments applied to RA-FLS or CIA mice for comparative study of therapeutic efficacy

From: Methotrexate-loaded multifunctional nanoparticles with near-infrared irradiation for the treatment of rheumatoid arthritis

GroupTreated contentIn vivoGroupTreated contentIn vitro
MTX dosage (mg/kg) and administration routeaNIR light (W/cm2)bMTX concentration (μM)cNIR light (W/cm2)d
Group 1SalineGroup 1Saline
Group 2MTX solution (high dose)35 × 8 times, IPGroup 2MTX solution (low dose)0.13
Group 3MTX solution (low dose)0.2 × 1 time, IVGroup 3MTX solution (high dose)30
Group 4MTX-unloaded MNPs–, IV1.96Group 4MTX-unloaded MNPs
Group 5MTX-loaded MNPs0.2, IVGroup 5MTX-unloaded MNPs + NIR0.38
Group 6MTX-loaded MNPs0.2, IV1.96Group 6MTX-loaded MNPs0.13
    Group 7MTX-loaded MNPs + NIR0.130.38
  1. aTreated volume of MNPs; 30 μl/ml, MNP concentration of 1 mg/ml. bThe arthritic limb was exposed to NIR light for 10 min using a laser diode (λ = 808 nm) 24 h post-injection. cTreated volume of MNPs; 30 μl/ml, MNP concentration of 1 mg/ml. dThe RA-FLS was exposed to NIR light for 10 min using a laser diode (λ = 808 nm) 24 h post-incubation