Variables | Young | Adult | Elderly | Very Elderly | p |
---|---|---|---|---|---|
N = 2483 | 63 | 2127 | 237 | 56 | |
Age, mean (SD) in years | 21.48 (4.48) | 47.91 (9.98) | 69.12 (2.87) | 78.81 (3.10) | |
Female gender (%) | 25 (39.68) | 1163 (54.68) | 171 (72.159) | 42 (75.09) | < 0.001 |
Disease duration, mean (SD) in years | 2.72 (3.39) | 7.28 (7.68) | 9.46 (9.40) | 8.19 (8.95) | < 0.001 |
Duration of biologic treatment, mean (SD) in years | 3.12 (3.409) | 2.60 (3.14) | 1.79 (2.18) | 1.57 (1.95) | < 0.001 |
Diagnosis,n(%) | |||||
RA, n = 1126 | 13 (1.15) | 903 (80.20) | 161 (14.30) | 49 (4.35) | < 0.001 |
PsA, n = 680 | 35 (5.15) | 610 (89.71) | 32 (4.71) | 3 (0.44) | |
AS, n = 677 | 15 (2.22) | 614 (90.69) | 44 (6.50) | 4 (0.59) | |
Comorbidities | |||||
Charlson Index, mean (SD) | 1.02 (0.13) | 1.25 (0.68) | 1.81 (1.49) | 2.07 (1.41) | < 0.001 |
Tobacco: smokers/past smokers, n (%) | 15 (23.81) | 645 (30.32) | 64 (27.00) | 7 (12.50) | 0.047 |
Concomitant immunosuppressive treatment,n(%) of use | |||||
MTX | 23 (41.8) | 943 (53.61) | 106 (55.79) | 27 (60.00) | 0.243 |
Corticosteroids | 15 (27.78) | 806 (46.51) | 129 (64.18) | 33 (71.74) | < 0.001 |
Initial corticoids dose (mg/day) | 15.55 (16.26) | 8.29 (7.24) | 8.03 (5.85) | 8.03 (6.37) | 0.011 |
Other | 8 (12.70) | 627 (29.48) | 83 (35.02) | 23 (41.07) | 0.002 |
First AE (Total),n(%) | 33 (52.4) | 1227 (57.7) | 147 (62.0) | 37 (66.1) | |
Infections | 9 (27.27) | 391 (31.87) | 50 (34.01) | 11 (29.73) | 0.789 |
Traumatic injuries | 2 (6.06) | 104 (8.48) | 14 (9.52) | 3 (8.11) | |
Neoplasms | 0 (0.00) | 28 (2.28) | 6 (4.08) | 1 (2.70) | |
Skin disorders | 5 (15.15) | 131 (10.68) | 15 (10.20) | 1 (2.70) | |
Others | 17 (51.52) | 573 (46.70) | 62 (42.18) | 21 (56.76) | |
First severe AE,n(%) | 4 (6.3) | 138 (6.5) | 36 (15.2) | 11 (19.6) | |
Infections | 1 (25.00) | 45 (32.61) | 13 (36.11) | 1 (9.09) | 0.052 |
Traumatic injuries | 0 (0.00) | 9 (6.52) | 2 (5.56) | 1 (9.09) | |
Neoplasms | 0 (0.00) | 17 (12.32) | 3.8 (8.33) | 0 (0.00) | |
Skin disorders | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (9.09) | |
Others | 3 (75.00) | 67 (48.55) | 18 (50.00) | 8 (72.73) | |
No AEn(%) | 30 (47.6) | 900 (42.3) | 90 (38.0) | 19 (33.9) |