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Table 3 Univariate GEE, longitudinal associations of the number of peripheral immune cells, and levels of serum cytokines with BVAS

From: Longitudinal immune cell monitoring identified CD14++ CD16+ intermediate monocyte as a marker of relapse in patients with ANCA-associated vasculitis

 

BVAS

β

95%CI

P value

CD4+ T

0.11

− 0.27 to 0.48

0.58

Th1

0.072

− 0.38 to 0.52

0.76

Th1 HLA-DR+

0.090

− 0.52 to 0.69

0.77

Th2

0.092

− 0.34 to 0.52

0.67

Th2 HLA-DR+

− 0.074

− 0.75 to 0.61

0.83

Th17

0.098

− 0.15 to 0.35

0.45

Th17 HLA-DR+

0.29

− 0.060 to 0.65

0.10

Treg

− 0.041

− 0.30 to 0.22

0.76

Treg HLA-DR+

0.030

− 0.35 to 0.41

0.88

Tfh

0.12

− 0.15 to 0.40

0.38

CD8+ T

0.23

− 0.15 to 0.62

0.24

CD8 HLA-DR+

0.24

− 0.18 to 0.66

0.27

CD19+ B

0.32

− 0.041 to 0.69

0.082

Plasma cell

0.54

− 0.037 to 1.1

0.067

Monocyte

0.66

0.048–1.3

0.035

CD14++ CD16-

0.61

0.018–1.2

0.043

CD14++ CD16+

0.82

0.25–1.4

0.005

CD14+ CD16+

0.62

− 0.21 to 1.5

0.14

Eosinophil

0.56

0.026–1.1

0.040

Neutrophil

− 0.066

− 0.57 to 0.44

0.80

IFN-γ

0.51

− 0.13 to 1.1

0.12

IL-1β

1.0

0.57–1.5

< 0.001

IL-6

0.89

0.56–1.2

< 0.001

IL-8

0.60

0.10–1.1

0.018

IL-10

0.51

− 0.077 to 1.1

0.088

TNF-α

0.91

0.43–1.4

< 0.001

  1. Longitudinal relationship of the number of peripheral immune cells and levels of serum cytokines with BVAS. Values in bold are statistically significant (P < 0.05). Th helper T, Treg regulatory T, Tfh follicular helper T, IFN interferon, IL interleukin