Table 1 Clinical data, imaging and patient history used for the creation of the score (CIP-DUS)
Feature | OR (95% CI) | P value | Sensitivity* | Specificity* | AUC/cvAUC | Weight | |
|---|---|---|---|---|---|---|---|
Clinical data and patient history | Smoker at baseline | OR 2.4 (0.6–8.7) | 0.28 | 22.7 | 88.9 | – | – |
SSc diffuse subtype | OR 4.1 (1.5–11.7) | 0.01 | 59.1% | 74.1% | 0.67/0.65 | 1 | |
Modified Rodnan skin score > 8 | OR 9.4 (3.0–29.2) | < 0.01 | 68.2% | 81.5% | 0.75/0.73 | 2 | |
Pulmonary arterial hypertension | OR 4.7 (1.2–18.7) | 0.03 | 27.3% | 92.6% | 0.56/0.54 | 1 | |
Present digital ulcers or pitting scars at baseline | OR 15.7 (3.3–74.3) | < 0.01 | 90.9% | 61.1% | 0.76/0.76 | 3 | |
History of digital ulcer or pitting scars | OR 36.2 (2.1–626.9) | < 0.01 | 100.0% | 44.4% | 0.78/0.77 | 3 | |
NC | NC pattern (defined by Cutolo et al. 2000) | OR 18.6 (1.1–326.4) | < 0.01 | 100.0% | 28.9% | ||
- Early | 0.58/0.55 | 1 | |||||
- Active | 0.69/0.67 | 2 | |||||
- Late | 0.78/0.76 | 3 | |||||
Late NC pattern vs. other NC patterns | OR 1.476 (0.5–4.0) | 0.46 | 50.0% | 59.6% | 0.56/0.55 | – | |
Reduced capillary density (n < 7/mm) in digit III of the right hand in NC | OR 9.0 (1.1–73.6) | 0.03 | 94.7% | 33.3% | 0.62/0.61 | 1 | |
FOI | Missing initial enhancement in FOI in digit III of the right hand | OR 3.9 (1.2–12.8) | 0.03 | 56.3% | 75.0% | 0.63/0.61 | 1 |
Missing initial enhancement in FOI in ≥ 1 digit | OR 0.9 (0.3–2.8) | 1.00 (ns) | 62.5% | 34.1% | – | – | |
Complete disruption in FOI in ≥ 1 digit | OR 1.3 (0.3–5.9) | 0.70 (ns) | 25.0% | 84.1% | – | – | |
CDUS | Percentage of pathologic (i.e. narrowed or occluded) vessels > 35% in CDUS | OR 4.3 (1.5–12.4) | 0.01 | 68.2% | 66. 7% | 0.67/0.64 | 1 |
≥ 1 pathologic vessel in CDUS in in digit III of the right hand | OR 3.8 (1.0–14.6) | 0.05 | 90.9 | 28.3 | – | – |