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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis

Fig. 2

Overview of the distribution of the significant differentially expressed proteins among the three time points. a Venn diagram indicating the number of shared and unique proteins in Sle123 compared to control mice at 12, 24 and 36 weeks. The overlapping areas represent the common proteins. bd Bar charts showing the fold change status of the common proteins among all three time points, 24 versus 36 weeks and 12 versus 24 weeks, respectively. The horizontal axis represents the gene symbol of each protein, and the vertical axis represents the log2 fold change (FC). Differentially expressed proteins identified by discovery proteomics at 12, 24 and 36 weeks with fold change ≥ 1.5, OR ≤ 0.67 and p value ≤ 0.05, were used for this analysis. Fold change values were scored as disease/controls. FC status indicates differences in the normalized protein abundances between cases and controls. eg Whiskers plots showing the normalized protein abundances between cases and controls at the three different time points for the target proteins, Coro1A, Arhgdib and Isg15, respectively. The p values and q values as calculated by Progenesis QIp are also shown. h Whiskers plot showing the normalized protein abundances between cases and controls at the different time points for the Dj-1 protein used for normalization purposes. Asterisks denote UniProtKB accession numbers of proteins without available gene symbols. P01864*, Ig gamma-2A chain C region secreted form; P18528*, Ig heavy chain V region 6.96; P18526*, Ig heavy chain V region 345; P06330*, Ig heavy chain V region AC38 205.12; P01837*, Ig kappa chain C region; P01644*, Ig kappa chain V-V region HP R16.7; P01631*, Ig kappa chain V-II region 26-10; P04945*, Ig kappa chain V-VI region NQ2-6.1. W, Weeks, C57/Bl6 (B6), FC, fold change; Coro1A, Coronin-1A; Arhgdib, Rho GDP-dissociation inhibitor 2; Isg15, Ubiquitin-like protein ISG15, DJ-1; Protein/nucleic acid deglycase

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