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Table 2 Histopathology evaluation of kidneys from Sle123 discovery set

From: Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis

Animals

Glomerulus

Tubules

Hypercell/PMN/cell debris

Thrombi/fibrosis

Interstitial inflammation

Tubular involvement/atrophy

12 weeks

1

0

0

0

0

2

0

0

0

0

3

0

0

0

0

4

0

0

0

0

5

0

0

0

0

Mean

0

0

0

0

24 weeks

1

3

1

1

1

2

1

0

0

0

3

1

0

1

0

4

3

1

3

1

5

0

0

1

2

Mean

1.6

0.4

1.2

0.8

36 weeks

1

2

3

3

1

2

1

0

0

0

3

1

0

1

0

4

1

0

0

0

5

3

0

3

2

Mean

1.6

0.6

1.4

0.6

  1. Grading: 0 = normal, 1 = mild, 2 = moderate, 3 = severe. PMN Polymorphonuclear neutrophils