Skip to main content

Table 4 Top 20 significantly enriched KEGG pathways of differentially expressed proteins identified by discovery proteomics

From: Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis

KEGG pathway

KEGG ID

Hits

p value

FDR

12 weeks

 Metabolic pathways

mmu01100

483

1.45E−62

1.92E−61

 Biosynthesis of antibiotics

mmu01130

144

4.13E−52

5.47E−51

 Carbon metabolism

mmu01200

85

6.32E−35

8.38E−34

 Oxidative phosphorylation

mmu00190

94

4.13E−34

5.48E−33

 Parkinson’s disease

mmu05012

91

4.78E−28

6.35E−27

 Alzheimer’s disease

mmu05010

94

8.33E−23

1.11E−21

 Ribosome

mmu03010

82

2.94E−22

3.90E−21

 Huntington’s disease

mmu05016

97

2.92E−20

3.88E−19

 Valine, leucine and isoleucine degradation

mmu00280

43

1.66E−19

2.20E−18

 Glycolysis/gluconeogenesis

mmu00010

47

1.46E−18

1.93E−17

 Pyruvate metabolism

mmu00620

33

8.28E−17

1.44E−15

 Non-alcoholic fatty liver disease (NAFLD)

mmu04932

75

5.96E−15

7.95E−14

 Propanoate metabolism

mmu00640

25

1.82E−14

2.42E−13

 Biosynthesis of amino acids

mmu01230

46

3.93E−14

5.21E−13

 Fatty acid degradation

mmu00071

35

6.34E−14

8.41E−13

 Peroxisome

mmu04146

48

1.10E−13

1.46E−12

 Citrate cycle (TCA cycle)

mmu00020

27

1.15E−13

1.53E−12

 Proteasome

mmu03050

33

1.18E−13

1.56E−12

 Glutathione metabolism

mmu00480

36

1.39E−12

1.84E−11

 Glycine, serine and threonine metabolism

mmu00260

28

6.95E−11

9.22E−10

24 weeks

 Metabolic pathways

mmu01100

490

1.27E−57

1.69E−56

 Biosynthesis of antibiotics

mmu01130

144

4.10E−49

5.45E−48

 Carbon metabolism

mmu01200

87

3.25E−35

4.32E−34

 Oxidative phosphorylation

mmu00190

97

5.63E−35

7.49E−34

 Parkinson’s disease

mmu05012

96

2.40E−30

3.19E−29

 Alzheimer’s disease

mmu05010

98

9.13E−24

1.21E−22

 Huntington’s disease

mmu05016

102

1.41E−21

1.88E−20

 Ribosome

mmu03010

82

9.71E−21

1.29E−19

 Glycolysis/gluconeogenesis

mmu00010

50

1.35E−20

1.79E−19

 Valine, leucine and isoleucine degradation

mmu00280

43

1.30E−18

1.72E−17

 Pyruvate metabolism

mmu00620

34

2.25E−17

2.99E−16

 Propanoate metabolism

mmu00640

26

1.88E−15

2.51E−14

 Fatty acid degradation

mmu00071

37

3.48E−15

4.57E−14

 Biosynthesis of amino acids

mmu01230

47

4.93E−14

6.55E−13

 Citrate cycle (TCA cycle)

mmu00020

27

4.22E−13

5.60E−12

 Proteasome

mmu03050

33

5.43E−13

7.22E−12

 Non-alcoholic fatty liver disease (NAFLD)

mmu04932

73

1.26E−12

1.67E−11

 Peroxisome

mmu04146

47

4.19E−12

5.57E−11

 Glutathione metabolism

mmu00480

36

6.85E−12

9.10E−11

 Fatty acid metabolism

mmu01212

32

5.96E−10

7.93E−09

36 weeks

 Metabolic pathways

mmu01100

539

3.89E−63

5.17E−62

 Biosynthesis of antibiotics

mmu01130

152

3.49E−50

4.64E−49

 Carbon metabolism

mmu01200

94

6.45E−39

8.58E−38

 Oxidative phosphorylation

mmu00190

100

1.22E−33

1.62E−32

 Parkinson’s disease

mmu05012

95

1.04E−25

1.38E−24

 Ribosome

mmu03010

90

3.47E−23

4.61E−22

 Alzheimer’s disease

mmu05010

101

4.65E−22

6.18E−21

 Glycolysis/gluconeogenesis

mmu00010

49

1.58E−17

2.10E−16

 Huntington’s disease

mmu05016

101

1.91E−17

2.54E−16

 Valine, leucine and isoleucine degradation

mmu00280

43

8.57E−17

1.44E−15

 Biosynthesis of amino acids

mmu01230

52

4.61E−16

5.88E−15

 Pyruvate metabolism

mmu00620

34

6.83E−16

8.88E−15

 Proteasome

mmu03050

36

1.35E−14

1.80E−13

 Non-alcoholic fatty liver disease (NAFLD)

mmu04932

81

2.34E−14

3.11E−13

 Propanoate metabolism

mmu00640

25

7.73E−13

1.03E−11

 Fatty acid degradation

mmu00071

36

1.04E−12

1.39E−11

 Glutathione metabolism

mmu00480

38

4.26E−12

5.66E−11

 Citrate cycle (TCA cycle)

mmu00020

27

5.98E−12

7.95E−11

 Peroxisome

mmu04146

49

1.09E−11

1.45E−10

 Fatty acid metabolism

mmu01212

34

3.02E−10

4.01E−09

  1. All 20 pathways are common at all three time points. The total list of significantly dysregulated pathways is found in supplementary tables, S3.1, S3.2 and S3.3. Analysis was performed using Database for Annotation, Visualization and Integrated Discovery (DAVID) bioinformatics resources