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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: An integrative Bayesian network approach to highlight key drivers in systemic lupus erythematosus

Fig. 1

Workflow and analysis procedure to identify signaling pathway alterations in SLE patients. At the first step, human peripheral blood mononuclear cell (PBMC) microarray datasets associated with SLE, which were generated using three platforms, were downloaded and each paired data related to the same platform integrated by CPN method. Subsequently, SLE, TCR, and BCR signaling pathways were employed as structures of BNs and trained by three major datasets independently by BNrich method. Afterwards, the differences between any paired corresponding parameters related to patients and controls were examined by independent t test. Consequently, the significant parameters merged by the mixture model to achieve the key driver parameters in studied pathways

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