Fig. 3
From: An integrative Bayesian network approach to highlight key drivers in systemic lupus erythematosus
The alterations in SLE signaling pathway based on calculated final parameters. The representation design of KEGG-extracted SLE signaling pathways (a), genes involved in autoantigen clearance (b), antigen presentation mediated by MHCII (c), and tissue injury and end-organ damage (d). The color and size of nodes reflect the values and the absolute values of the μ∗(βf), respectively, and it is equivalent to the upregulation or downregulation of genes. Moreover, the color of the edges reflects the values of the μ∗(βf), respectively, and it is equivalent to the increasing or decreasing biological function