Table 4 Baseline biomarker concentrations and MBDA scores in the groups with persistent disease activity, intermittent remission and sustained remission over 12 months
From: A multi-biomarker disease activity score can predict sustained remission in rheumatoid arthritis
|  | PDA (n = 14) | DAS28-IR (n = 62) | DAS28-SR (n = 69) | p value | SDAI-IR (n = 67) | SDAI-SR (n = 29) | p value | ACR/EULAR Boolean-IR (n = 52) | ACR/EULAR Boolean-SR (n = 14) | p value |
|---|---|---|---|---|---|---|---|---|---|---|
EGF (pg/ml) | 287 (162, 368) | 235 (181, 334) | 246 (148, 368) | ns | 245 (148, 356) | 249 (145, 339) | ns | 228 (154, 338) | 253 (145, 397) | ns |
IL-6 (pg/ml) | 14 (10, 24) | 12 (7, 21) | 8 (5, 12) | 0.0001 | 8.46 (5.97, 13.21) | 6.16 (4.24, 10.21) | 0.0008 | 7.13 (5.41, 12.00) | 7.79 (5.58, 9.33) | 0.0056 |
Leptin (ng/ml) | 25 (10, 35) | 16 (6, 33) | 7 (4, 16) | 0.0006 | 11 (4, 24) | 6 (4, 11) | 0.009 | 7.87 (4.12, 2.34) | 6.74 (3.44, 14) | 0.031 |
MMP-1 (ng/ml) | 5.10 (3.82, 8.99) | 6.79 (4.87, 9.34) | 7.08 (3.54, 9.61) | ns | 7.26 (5.05, 10.49) | 6.84 (4.53, 9.12) | ns | 6.62 (5.06, 10.01) | 7.95 (4.60, 8.71) | ns |
MMP-3 (ng/ml) | 27 (14, 43) | 24 (17, 34) | 27 (19, 37) | ns | 27 (21, 40) | 20 (15, 32) | ns | 27 (16, 34) | 19 (15, 33) | ns |
Resistin (ng/ml) | 9.10 (6.47, 12.49) | 7 (5, 9) | 8 (6,9) | ns | 7.01 (5.91, 8.44) | 7.99 (5.84, 9.88) | ns | 7.02 (5.87, 8.94) | 8.14 (7.58, 10.25) | ns |
SAA (ug/ml) | 2.82 (1.84, 8.75) | 1.73 (1.06, 3.74) | 1.23 (0.64, 2.51) | 0.0012 | 1.69 (0.70, 3.10) | 1.09 (0.64, 1.70) | 0.0013 | 1.54 (0.85, 2.47) | 1.14 (6.43, 2.21) | 0.0062 |
TNFR1 (ng/ml) | 1.66 (1.39, 2.11) | 1.56 (1.35, 1.94) | 1.50 (1.32, 1.99) | ns | 1.51 (1.32, 1.94) | 1.50 (1.31, 1.90) | ns | 1.55 (1.35, 2.01) | 1.73 (1,31, 2.06) | ns |
VCAM1 (ng/ml) | 587 (528, 693) | 524 (409, 652) | 533 (457, 621) | ns | 509 (421, 621) | 521 (457, 596) | ns | 532 (427, 626) | 511 (458, 596) | ns |
VEGF (pg/ml) | 330 (260, 478) | 263 (190, 368) | 247 (173, 393) | ns | 247 (186, 372) | 215 (150, 408) | ns | 218 (154, 385) | 208 (170, 330) | ns |
YKL40 (ng/ml) | 70 (45, 98) | 57 (38, 86) | 53 (36, 92) | ns | 50 (36, 69) | 48 (32, 127) | ns | 55 (33, 92) | 60 (48, 13) | ns |
CRP (mg/ml) | 6.63 (4.99, 10.50) | 2.98 (1.25, 7.39) | 1.40 (0.61, 2.70) | < 0.0001 | 1.65 (1.03, 3.50) | 1.32 (0.35, 2.34) | < 0.0001 | 2.06 (0.79, 2.98) | 1.15 (0.21, 2.49) | < 0.0001 |
MBDA score | 40 (31, 50) | 34 (21, 43) | 23 (16, 35) | < 0.0001 | 29 (18, 35) | 17 (15, 35) | 0.0002 | 26 (17, 37) | 21.5 (15, 37) | 0.0025 |