Fig. 4

PRΔPrx1-CIA mice had lower subchondral trabecular bone volume. (a) Representative Safranin-O-stained knee histologic images from female or (b) male in WT or PRΔPrx1 normal or CIA mice. (c) Quantitative measurements of subchondral trabecular bone or cortical plate thickness at the femoral epiphyses. Black stars indicate inflamed synovial tissue. *p < 0.05 between indicated groups. Scale bar = 100 μm