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Table 2 Regression analyses of predictive factors on the likelihood of LD presence in AOSD

From: Parenchymal lung disease in adult onset Still’s disease: an emergent marker of disease severity—characterisation and predictive factors from Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort of patients

Clinical variables

OR

95%CI

p

Univariate analyses

 Age

1.04

1.01–1.07

0.021

 Male gender

0.61

0.23–1.65

0.332

 Arthritis

1.05

0.22–5.04

0.95

 Skin Rash

0.86

0.28–2.59

0.786

 Myalgia

5.06

1.12–22.97

0.036

 Splenomegaly

1.87

0.58–6.03

0.290

 Lymph node involvement

3.34

1.04–10.69

0.042

 Sore throat

1.63

0.58–4.62

0.355

 Liver Involvement

0.96

0.35–2.65

0.941

 Pleuritis

7.34

2.53–20.67

< 0.001

 Pericarditis

2.78

0.98–7.92

0.060

 Abdominal pain

7.80

2.59–23.51

< 0.001

 Systemic score

2.14

1.54–2.97

< 0.001

 Systemic score ≥ 7

19.16

4.20–87.41

< 0.001

 MAS

1.39

0.42–4.62

0.592

 Leucocytosis > 15,000/mm3

1.45

0.53–3.99

0.467

 ESR

1.01

0.98–1.02

0.819

 CRP

1.32

0.85–2.06

0.214

 Ferritin

1.48

0.95–2.31

0.083

 Low dosage of GCs

0.36

0.11–1.16

0.086

 Synthetic DMARDs

0.84

0.30–2.32

0.739

 Biologic DMARDs

0.88

0.29–2.66

0.831

 Monocyclic Pattern

0.87

0.31–2.48

0.798

 Polycyclic disease pattern

0.23

0.05–1.02

0.064

 Chronic disease pattern

0.80

0.25–2.59

0.708

Multivariate analyses

 Age

1.04

1.01–1.08

0.044

 Systemic score

2.08

1.50–2.88

< 0.001

X2 = 28.72, p < 0.001

Age

1.05

1.01–1.09

0.011

 Systemic score ≥ 7

23.31

4.85–42.08

< 0.001

X2 = 23.06, p < 0.001

  1. MRI magnetic resonance imaging, AOSD adult onset Still’s disease, ESR erythrocyte sedimentation rate, CRP C-reactive protein, GCs glucocorticoids, DMARDs disease-modifying anti-rheumatic drugs. Bolded values are statistically significant (p < 0.05)