Fig. 4

Weighted gene co-expression network analysis of B cell subsets of patients with pSS. a Principal component analysis using the gene set produced is generated using WGCNA. The ellipse shows the 50% confidence interval of the value of principal component analysis. b Module eigengene of each B cell subset of patients with pSS. The y-axis displays the values of the module eigengene, and the x-axis displays each cell subset. c The heatmap shows module-trait associations. Each row corresponds to a module’s first eigengene and columns to a measured value of trait. Each cell contains the corresponding Spearman’s correlation coefficient (p value) between a measured value of each trait and a module’s first eigengene. CRP, C-reactive protein; ESSDAI, EULAR Sjögren’s Syndrome Disease Activity Index; GC-B, germinal centre B cell; Lym, lymphocyte count; SS.A, anti-Sjögren’s syndrome-related antigen A; ME, module eigengene; SS.B, anti-Sjögren’s syndrome-related antigen B