Fig. 4
From: Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase
Net cytokine secretion by PG antigen-stimulated spleen cells from PG-immunized WT, Shp1-Tg+/+, and Shp1-Tg+/− mice. a IFNγ, b IL-17, c IL-10, and d IL-4. Spleen cells of PG-immunized (or naïve WT) mice were stimulated with PG antigen in vitro for 4 days, then secreted cytokines were measured in the cell culture supernatants. Net cytokine secretion (pg/ml) is illustrated as stimulated minus non-stimulated values (mean ± SEM, n = 4–15/group, *p < 0.05, **p < 0.01, ***p < 0.001, one-way ANOVA)