Fig. 1From: Profiling of IgG antibodies targeting unmodified and corresponding citrullinated autoantigens in a multicenter national cohort of early arthritis in Germanya Detection rates of IgG antibodies to citrullinated and uncitrullinated forms of 390 distinct proteins in patients diagnosed with rheumatoid arthritis (RA patients) (n = 309) out of an early arthritis cohort (n = 411). Each dot represents the percentage of patients with an increased IgG detection towards a distinct citrullinated or uncitrullinated protein. Regression line with 95% confidence interval depicted (Spearman’s r = 0.13, p = 0.01). b Venn diagram representing the number of patients with increased antibody reactivity in rheumatoid arthritis (RA) patients and control patients (non-RA patients) classified as RA by three distinct autoantibodies against citrullinated peptides (ACPA), citrullinated “transformer 2 beta homolog” (cTRA2B), and rheumatoid factor (RF) as well as the respective overlaps. c Proportion of patients who were subsequently diagnosed with RA or not according to a diagnostic score of ≥ 2 (n = 140) or below (n = 271) based on adjusted odds ratios of multivariable generalized linear modeling (ACPA 3 points, RF and cTRA2B 1 point each)Back to article page