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Table 2 Diagnostic properties of candidate diagnostic antibodies

From: Profiling of IgG antibodies targeting unmodified and corresponding citrullinated autoantigens in a multicenter national cohort of early arthritis in Germany

Symbol Name Sens 90% spec Spec Sens OR p Adj. p
cPDRG1 p53 and DNA damage regulated 1 15.4 (8.7–24.9) 42.1 73.5 7.23E+02 0.121 0.479
PDGR1 p53 and DNA damage regulated 1 19.8 (8.7–27.7) 81.6 30.8 6.45E+02 0.099 0.479
cFAM234A Family with sequence similarity 234 A 24.1 (11.1–41.1) 82.9 39.9 1.12E+03 0.091 0.479
FAM234A Family with sequence similarity 234 A 19.0 (11.1–33.2) 71.1 51.0 5.12E+02 0.058 0.450
cRBMS1 RNA binding motif ss interacting prot 1 30 (22.9–37.6) 94.7 27.7 2.33E+02 0.003 0.097
cILKAP ILK ass. Serine/threonine phosphatase 25.3 (13.4–43.1) 59.2 66.8 1.42E+02 0.012 0.250
cPIN1 Peptidylprolyl cis/trans isomerase NIMA-interacting 1 26.5 (15.8–38.7) 88.2 32.8 1.96E+05 0.080 0.479
cPEX14 Peroxisomal biogenesis factor 14 22.1 (12.6–34.0) 75 50.2 1.61E+04 0.056 0.450
cC21orf91 Chromosome 21 open reading frame 91 24.1 (17.0–35.2) 55.3 61.7 3.52E+05 0.011 0.250
cCMPK1 Cytidine/uridine monophosphate kinase 24.1 (18.2–31.6) 97.4 20.6 3.88E+01 0.003 0.089
cSIGIRR Single Ig and TIR domain containing 32.8 (23.3–44.7) 81.6 44.7 8.85E+03 0.006 0.154
cTRADD TNFRSF1A associated via death domain 28.5 (19.8–37.9) 69.7 55.7 9.96E+01 0.002 0.079
cHNRNPA1 Heterogeneous nuclear ribonucleo-protein A1 21.7 (13.4–34.0) 68.4 48.6 1.96E+01 0.034 0.374
cPODXL2 Podocalyxin like 2 28.1 (19.8–38.3) 80.3 41.9 2.13E+02 0.024 0.363
cPER1 Period circadian regulator 1 24.1 (7.9–36.8) 77.6 42.3 4.65E+01 0.157 0.479
cAEBP1 AE binding protein 1 21.7 (13.0–36.8) 68.4 55.7 1.75E+02 0.014 0.270
cHYOU1 Hypoxia upregulated 1 23.3 (14.2–36.4) 81.6 39.1 3.07E+03 0.026 0.366
cTRA2B Transformer 2 beta homolog 39.1 (29.2–51.4) 82.9 51 5.26E+03 0.001 0.047
cSNRNP70 Small nuclear ribonucleoprotein U1 subunit 70 28.5 (14.6–43.1) 81.6 45.8 5.64E+02 0.003 0.099
cNUMA1 Nuclear mitotic apparatus protein 1 29.6 (13.0–39.1) 89.5 32.4 9.23E+03 0.040 0.374
cCRIP2 Cysteine rich protein 2 28.9 (13.0–39.5) 90.8 31.2 2.50E+02 0.009 0.204
cPIP5K1C Open reading frame 31.2 (17.0–41.9) 78.9 47 1.09E+04 0.005 0.120
cRPRM Reprimo. TP53 dependent G2 arrest mediator homolog 33.6 (23.3–44.7) 78.9 47.8 1.57E+03 0.004 0.101
cVPS4A Vacuolar protein sorting 4 homolog A 22.9 (15.4–30.4) 67.1 52.2 3.49E+01 0.020 0.313
cNUDT16 Nudix hydrolase 16 31.6 (22.9–42.3) 86.8 38.3 9.07E+05 0.003 0.099
cASMTL Acetylserotonin O-methyltransferase like 36.4 (26.1–44.3) 92.1 35.6 1.63E+04 0.006 0.138
cNONO Non-POU domain containing octamer binding 24.1 (13.8–32.0) 51.3 65.2 5.34E+01 0.014 0.270
cCASKIN1 CASK interacting protein 1 20.9 (11.5–28.5) 75 47.8 1.56E+04 0.037 0.374
cSPTBN2 Spectrin beta. Non-erythrocytic 2 25.7 (11.9–35.2) 63.2 55.7 9.17E+02 0.029 0.373
cKIF5B Kinesin family member 5B 23.7 (15.8–35.2) 85.5 31.6 2.49E+02 0.017 0.287
cGLT8D1 Glycosyltransferase 8 domain containing 1 24.1 (15.0–36.8) 81.6 39.9 9.56E+01 0.015 0.270
cEIF4H Eukaryotic translation initiation factor 4H 28.9 (20.2–38.7) 77.6 45.8 1.29E+03 0.004 0.099
cZNF579 Zinc finger protein 579 18.6 (8.7–33.2) 81.6 34.4 2.81E+01 0.111 0.479
cSNRPB Small nuclear ribonucleoprotein polypeptides B and B1 17.0 (10.7–33.6) 82.9 32.8 5.67E+02 0.030 0.373
  1. Gene symbol with preceding “c” indicates antibody to citrullinated recombinant antigen. Sensitivity (Sens) at 90% specificity (Spec), otherwise at optimal area under the curve according to ROC analysis. Odds ratio (OR) for diagnosis of RA by generalized linear modeling with unadjusted p value (p), or after adjustment according to Bonferroni