Table 2 Current progress in genetic discoveries for some of the modifiable environmental risk factors
Traits | Author | Measures | Ancestry | Year | # Individuals | # IVs | Variance explained by genome-wide SNPs |
|---|---|---|---|---|---|---|---|
Smoking | Liu et al. | Smoking initiation (ever vs. never smoking) | European | 2019 | 1,232,091 | 378 | 8.0% |
Smoking | Liu et al. | Cigarette per day | European | 2019 | 337,334 | 55 | 7.8% |
Smoking | Liu et al. | Smoking cessation | European | 2019 | 547,219 | 24 | 4.6% |
Alcohol consumption | Liu et al. | Drinks per week | European | 2019 | 941,280 | 99 | 4.2% |
Physical activity | Doherty et al. | Accelerometer-measured overall physical activity | European | 2018 | 91,105 | 14 | 15% |
Physical activity | Klimentidis et al. | Self-reported habitual physical activity | European | 2018 | 337,234 | 8 | 5% |
Body mass index | Pulit et al. | Body mass index | European | 2018 | 694,649 | 941 | 22.4% |
Vitamin D | Revez et al. | Circulating vitamin D levels | European | 2019 | 417,580 | 143 | 13% |
Vitamin D | Manousaki et al. | Circulating vitamin D levels | European | 2020 | 401,460 | 138 | 4.9% |
Educational attainment | Lee et al. | Number of years of schooling | European | 2018 | 1,131,881 | 1271 | 12.2% |
Depression | Howard et al. | Major depression disorder | European | 2019 | 807,553 | 102 | 8.9% |
Mood change | Ward et al. | Mood instability | European | 2019 | 363,705 | 46 | 9.0% |