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Table 1 Characteristics of the study population before aHSCT

From: Low B cell counts as risk factor for infectious complications in systemic sclerosis after autologous hematopoietic stem cell transplantation

Characteristics Values
Female, % 47.1
Age at aHSCT, median (range), years 52.0 (23–64)
Disease duration before aHSCT, median (range), years 3.5 (0.3–13)
Diffuse cutaneous form, % 100
mRSS, median (range) points 23.0 (5–44)
Anti-nuclear antibody positivity, % 88.2
Anti-Scl-70 antibody positivity, % 64.7
Anti-Centromere antibody positivity, % 0
Smoking history, %
 Current 5.9
 Ever 41.2
Pulmonary fibrosis on thoracic computed tomography, % 82.4
FVC (% predicted) latest value before aHSCT, median (IQR) 74.0 (58.0–89.0)
DLCO (% predicted) latest value before aHSCT, median (IQR) 44.0 (29.0–59.0)
Troponin positivity, % 82.4
Abnormal 24 h Holter ECG, n (%) 1/15 (6.7)
Abnormal cardiac MRI, n (%) 6/13 (46.2)
Right heart catheterization, done 12/17
Pulmonal arterial hypertension, n (%) 2/12 (16.7)
Mean pulmonal arterial pressure (mPAP), mmHg, median (range) 18.0 (9–30)
Indication for aHSCT
 Skin, % 41.2
 Lung, % 35.3
 Skin and lung, % 23.5
Positive CMV-Serology, % 35.3
Positive EBV-Serology, % 100
  1. aHSCT autologous hematopoietic stem cell transplantation, CMV cytomegalovirus, DLCO diffusion capacity for carbon monoxide, EBV Epstein-Barr virus, FVC forced vital capacity, IQR inter quartile range, mRSS modified Rodnan skin score