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Table 3 Reconstitution of peripheral blood cells in percentages and absolute cell numbers per μl after aHSCT

From: Low B cell counts as risk factor for infectious complications in systemic sclerosis after autologous hematopoietic stem cell transplantation

  Percentages % (IQR) Numbers/μl × 103 (IQR)
Before aHSCT Month 1 Month 3 Month 6 Month 12 Before aHSCT Month 1 Month 3 Month 6 Month 12
Leucocytes na na na na na 9.8 (IQR 8.4–13.6) 10.7 (8.3–12.2) 7.6 (5.4–10.5) 7.1 (6.4–8.5) 7.1 (5.8–9.1)
Neutrophils 77.5 (67.8–83.5) 75.0 (70.5–82.0) 77.0 (69.8–86.3) 79.0 (65.5–82.0) 71.5 (62.0–79.3) 8.5 (6.1–10.8) 7.9 (5.9–9.7) 6.0 (4.3–8.0) 5.6 (4.3–6.4) 5.2 (3.7–7.1)
Lymphocytes 11.5 (7.3–18.0) 9.5 (5.3–14.8) 10.0 (6.8–17.3) 12.0 (6.5–22.0) 15.5 (11.0–21.0) 1.1 (0.8–1.9) 1.0 (0.6–1.4) 0.7 (0.5–1.0) 0.9 (0.5–1.6) 1.2 (0.5–1.5)
Monocytes 8.5 (5.3–10.8) 9.0 (6.3–13.0) 10.0 (5.0–13.3) 9.0 (7.5–12.0) 8.5 (7.3–10.0) 0.9 (0.5–1.1) 1.0 (0.6–1.4) 0.6 (0.5–0.9) 0.6 (0.4–1.0) 0.6 (0.5–0.9)
  % within the lymphocyte gate Numbers/μl
T cells CD3+ 72.0 (58.5–78.8) 51.5 (23.0–63.3) 37.0 (33.0–55.5) 46.0 (32.4–68.0) 60.0 (37.5–62.5) 745.5 (462.0–1593.7) 473.1 (150.5–837.6) 257.4 (187.5–433.4) 325.7 (165.7–796.2) 539.4 (237.2–775.6)
T helper cells CD3+/CD4+ 50.0 (37.0–57.0) 8.5 (4.3–11.8) 7.0 (4.5–10.8) 11.0 (5.3–17.3) 20.0 (15.0–26.5) 605.9 (325.6–829.0) 78.3 (36.7–160.7) 49.2 (28.4–95.2) 109.4 (26.7–202.1) 201.6 (75.8–396.9)
Cytotoxic T cells CD3+/CD8+ 14.0 (9.2–21.0) 39.0 (22.0–49.3) 28.5 (19.3–34.3) 20.5 (15.5–51.8) 32.0 (19.5–44.5) 146.3 (82.2–286.2) 335.7 (112.8–736.0) 174.8 (115.8–289.4) 140.9 (119.9–543.2) 228.3 (147.1–515.2)
CD4+/CD8+ ratio 3.4 (1.8–5.2) 0.3 (0.2–0.4) 0.3 (0.2–0.4) 0.3 (0.2–0.9) 0.5 (0.4–1.1) na na na na na
NK cells CD56/CD16+ 17.0 (6.0–20.0) 43.5 (25.5–55.8) 33.5 (22.8–44.3) 24.0 (17.3–36.0) 18.0 (10.0–35.5) 193.6 (103.4–247.5) 325.4 (240.8–534.9) 205.2 (149.5–346.5) 196.9 (134.3–309.1) 216.1 (123.1–283.0)
NKT cells CD3+/CD56/CD16+ 1.8 (1.0–3.2) 2.0 (0.4–3.2) 2.1 (0.2–3.2) 1.1 (0.4–3.4) 1.6 (1.0–2.2) 28.6 (10.3–50.8) 12.8 (4.6–33.7) 13.6 (3.5–23.6) 8.8 (4.8–32.1) 11.7 (5.8–26.6)
Total B cells CD19+ 5.9 (4.9–15.0) 1.2 (0.3–3.4) 13.5 (1.4–29.0) 22.0 (3.8–32.5) 24.0 (11.9–31.3) 83.2 (47.8–136.7) 7.9 (1.4–50.1) 138.9 (10.4–238.1) 215.0 (20.8–291.3) 291.0 (148.9–379.4)
  % within the CD19+ compartment      
Transitional B cells CD38++/CD10+/IgD+ 1.0 (0.3–6.7) 55.0 (7.5–81.8) 17.7 (13.4–50.4) 5.8 (3.5–19.3) 6.2 (1.6–16.1) 1.1 (0.2–15.7) 4.2 (0.1–12.5) 28.2 (3.4–47.7) 9.7 (2.0–92.1) 10.7 (5.5–49.6)
Double negative B cells CD27/IgD 3.1 (2.5–6.4) 3.9 (2.0–16.1) 0.8 (0.5–1.8) 1.4 (0.6–2.2) 1.6 (1.4–2.5) 3.6 (1.5–8.4) 1.2 (0.1–1.7) 1.2 (0.6–2.3) 2.0 (0.9–4.6) 5.8 (3.4–8.8)
Post-switched memory B cells CD27+/IgD 9.2 (4.1–18.3) 8.4 (0.9–55.3) 0.9 (0.5–1.9) 1.7 (0.5–5.0) 2.6 (1.1–2.9) 6.6 (4.3–13.1) 0.6 (0.2–1.0) 1.3 (0.4–2.2) 2.7 (0.6–5.2) 5.8 (3.1–10.7)
Pre-switched memory B cells CD27+/IgD+ 6.4 (3.0–10.8) 4.0 (2.3–7.5) 2.5 (1.7–6.3) 2.9 (2.1–4.1) 2.1 (1.8–4.2) 4.5 (1.8–10.8) 0.2 (0.1–1.7) 4.4 (0.9–6.0) 4.6 (1.1–11.0) 7.2 (4.4–11.3)
Naïve B cells CD27/IgD+ 77.0 (60.0–87.2) 76.6 (5.7–92.9) 95.3 (88.4–96.4) 93.8 (89.5–96.2) 92.4 (91.2–96.2) 58.9 (32.4–130.5) 6.1 (1.2–38.1) 127.4 (28.3–238.0) 212.1 (44.1–285.2) 293.0 (180.8–353.2)
  1. Shown are medians (interquartile range); na not applicable; n = 10–17
  2. Significant (P < 0.05) in a Wilcoxon signed-rank test compared to values before aHSCT