Fig. 1

Duration of interruptions in the phase 3 studies RA-BEGIN (a), RA-BEAM (b), RA-BEACON (c), and RA-BUILD (d)^a,b. ^aInterruptions are based on daily tablet baricitinib study drug, including in non-baricitinib groups, which represent interruptions of the matching placebo for baricitinib. ^bTemporary interruption is defined as a temporary withholding of study drug that is followed by resumption of study drug during the study. MTX, methotrexate