Fig. 5

μCT-based quantification and 3D images of joint space mineralisation with OA progression in Str/ort mice and in response to post-traumatic DMM surgery. a Analysis showed volume of mineralised tissue in the joint space increased with disease severity in Str/ort mice (n = 8) and healthy C57Bl/6 mice (n = 7). b This increase was also visualised in 3D as enlargement of the meniscus and ectopic mineralisation nodules of different sizes (distal and anterior views). c Similar increases in mineralised tissue volume were noted 8 weeks following DMM surgery compared to the contralateral control knee (n = 7), d with mineral nodules primarily in the medial side of the joint. (Lat = Lateral; Med = Medial; Ant = Anterior; Post = Posterior; Prox = Proximal; Dist = Distal). ***for p > 0.001, based on t test between control and DMM. Data presented as mean ± SEM