From: Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis
 | Spontaneous OA (Str/ort mouse) | Surgical model (DMM) |
---|---|---|
OA grade | 26 weeks, 2.57 ± 1.1 40 weeks, 3.62 ± 1.5 | 3.61 ± 0.3 |
Meniscus | ||
Meniscal osteophyte formation at tip | Grade 3–5 | Yes |
Outer part chondrogenesis | Grade 3–4 | Yes |
Outer part ossification | Grade 3–5 | Yes |
Hypertophy of attachment | Grade 4–6 | Yes |
Erosion | Grade 6 | Yes (grade 6) |
Ligaments (cruciates, collaterals) | ||
Strong ECM staining | Grade 3–6 | Yes |
Cell hypertrophy | Grade 3–6 | Yes |
Cell clustering | Grade 4–6 | Yes |
Loss of alignment | Grade 4–6 | Yes |
Ossification | Grade 4–6 | Yes |