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Table 1 Summary of meniscal and ligament changes in two murine models of knee osteoarthritis. Maximum OA grades reported for Str/ort mice based on the OARSI grading system, to group these changes according to the severity of OA in a model that shows variability

From: Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis

 

Spontaneous OA (Str/ort mouse)

Surgical model (DMM)

OA grade

26 weeks, 2.57 ± 1.1

40 weeks, 3.62 ± 1.5

3.61 ± 0.3

Meniscus

Meniscal osteophyte formation at tip

Grade 3–5

Yes

Outer part chondrogenesis

Grade 3–4

Yes

Outer part ossification

Grade 3–5

Yes

Hypertophy of attachment

Grade 4–6

Yes

Erosion

Grade 6

Yes (grade 6)

Ligaments (cruciates, collaterals)

Strong ECM staining

Grade 3–6

Yes

Cell hypertrophy

Grade 3–6

Yes

Cell clustering

Grade 4–6

Yes

Loss of alignment

Grade 4–6

Yes

Ossification

Grade 4–6

Yes