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Table 4 Overview of the impact of core outcome domains on the odds ratio (OR) for achieving primary endpoint per trial

From: Assessing the effect of interventions for axial spondyloarthritis according to the endorsed ASAS/OMERACT core outcome set: a meta-research study of trials included in Cochrane reviews

  Univariate meta-regression analysis based on trials reporting primary endpoint Univariate meta-regression analysis based on trials reporting all four domains significantly affecting primary endpoint** (k = 15) Multivariable meta-regression analysis based on trials reporting all four domains significantly affecting primary endpoint** (k = 15)
Domain k OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
Overall* 39 3.26 (2.58, 4.13) < 0.001 3.72 (2.92, 4.74) < 0.001   
PF 31 2.79 (1.58, 4.90) 0.001 3.9 (1.67, 9.15) 0.005 0.56 (0.27, 1.16) 0.105
Pain 27 2.11 (1.45, 3.06) < 0.001 5.6 (2.4, 13.15) 0.001 5.19 (2.28, 11.77) 0.001
SM 31 1.20 (0.94, 1.5) 0.142 2.25 (1.27, 3.99) 0.009 1.03 (0.64, 1.68) 0.883
SS 22 1.29 (0.81, 2.06) 0.268 1.88 (0.62, 1.56) 0.227
PGA 20 2.15 (1.41, 3.30) 0.001 2.58 (1.53, 4.34) 0.002 1.87 (1.14, 3.07) 0.018
PJ/E 10 8.14 (0.36, 186.27) 0.161 16.99 (0.00, 3687 0.403
APR 23 1.68 (1.05, 2.68) 0.031 1.61 (0.99, 2.63) 0.054 0.86 (0.58, 1.29) 0.381
SR
Fatigue 4 2.59 (0.00, 1360) 0.581
  1. *Based on trials reporting primary outcome; PF physical function, SM spinal mobility, SS spinal stiffness, APR acute phase reactants, SR spine radiographs
  2. **PF, Pain, PGA, APR