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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Fig. 5

OSMRβ mediates OSM-induced EC activation in HDMECs. a Effect of OSMRβ and LIFR inhibition on OSM-induced mRNA levels. HDMECs were transfected with specific siRNA against OSMRβ, LIFR separately, or together for 24 h and then treated with OSM for another 24 h. b mRNA levels of TGFβ3, SNAIL1, IL-6, and TIMP1 were analyzed by quantitative PCR, n = 3. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. c-e Effect of STAT3 inhibition on OSM-induced mRNA levels. HDMECs were pretreated with an inhibitor of STAT3 (BP-1-102) and then treated with OSM for 3 h and 24 h. mRNA levels of IL-6, TGFβ3, and TIMP1 were analyzed by quantitative PCR, n = 3. *p < 0.05, **p < 0.01

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