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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: IL13Rα1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes

Fig. 1

IL13Rα1 is responsive to ER stress and promotes apoptosis of RA FLSs. ac RT-qPCR, Western blot (WB), and IHC analyses of IL13Rα1 in the synovial tissues from RA (n = 12) and OA (n = 8) patients. Band intensity given underneath gel images was measured using ImageJ software (NIH, Bethesda, MD, USA) and presented as fold change compared with the first RA sample. d IF analysis of IL13Rα1 (green) in RA FLSs with the stimulation of Tunicamycin (Tm, 5 μg/mL), Thapsigargin (Tg, 100 nM), or cobalt chloride (CoCl2, 10 μM) for 12 h. e IB analyses of IL13Rα1 in RA FLSs with the stimulation of Tm, Tg, and CoCl2 as indicated doses for 12 h. Data in d and e represent three independent experiments from three different RA samples with similar results. **p < 0.01compared with RA

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