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Table 2 Identified risk factors for allopurinol-induced MCARs

From: Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study

Risk factors MCAR (n = 74) Control (n = 395) OR (95% CI) P value
Age, years, mean (SD)
 ≤ 40 29 (39.2) 135 (34.2) 1.28 (0.76–2.13) 0.35
 40–65 42 (56.8) 249 (63.0) 1  
 > 65 3 (4.0) 11 (2.8) 1.79 (0.44–5.67) 0.38
Female, n (%) 0 0   1
History of allopurinol-induced skin reaction, n (%) 2 (2.7) 0 27 (2–3777) 0.01
Asymptomatic hyperuricemia, n (%) 2 (2.7) 0 NA NA
Allopurinol starting dose > 150 mg/day, n (%) 3 (4.1) 7 (1.8) 2.5 (0.6–8.7) 0.19
Concomitant diuretics intake, n (%) 1 (1.4) 0 16 (0.9–2365) 0.06
eGFR < 60 ml/min/1.73 m2, n (%) 6 (8.1) 7 (1.8) 4.9 (1.6–14.6) 0.006
HLA-B*58:01-positive, n (%) 6 (8.1) 29 (7.3) 1.18 (0.45–2.7) 0.72
  1. OR odds ratio, 95% CI 95% confidence interval, NA not applicable