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Table 3 Identified risk factors for allopurinol-induced SCARs

From: Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study

Risk factors SCARs (n = 31) Control (n = 395) OR (95% CI) P value
Age, years, mean (SD)
 ≤ 40 2 (6.9) 135 (34.2) 0.28 (0.05–0.91) 0.04
 40–65 16 (55.2) 249 (63.0) 1  
 > 65 11 (37.9) 11 (2.8) 15.1 (5.8–40.1) < 0.0001
Female, n (%) 9 (29.0) 0 333 (40–43,453) < 0.0001
History of allopurinol-induced skin reaction, n (%) 2/27 (7.4) 0 78 (6–10,808) 0.004
Asymptomatic hyperuricemia, n (%) 15/27 (55.6) 0 NA NA
Allopurinol starting dose > 150 mg/day, n (%) 27 (87.1) 7 (1.8) 316 (101–1224) < 0.0001
Concomitant diuretics intake, n (%) 7/26 (26.9) 0 304 (35–40,018) < 0.0001
eGFR < 60 ml/min/1.73 m2, n (%) 12/18 (66.7) 7 (1.8) 100 (32–353) < 0.0001
HLA-B*58:01-positive, n (%) 29 (93.5) 29 (7.3) 147 (45–746) < 0.0001
  1. NA not applicable