Association between knee alignment, osteoarthritis disease severity, and subchondral trabecular bone microarchitecture in patients with knee osteoarthritis: a cross-sectional study

Table 3 Summary of multiple linear regression analysis, for prediction of medial and lateral tibial plateau subchondral trabecular bone microarchitecture parameters

Dependent variables	Model	R² (p value)	ΔR² (p value)
Medial
BV/TV	Age, sex, BMI	0.182 (0.004)
BV/TV	Age, sex, BMI, HKA angle	0.509 (< 0.001)	0.326 (< 0.001)
Tb.N	Age, sex, BMI	0.213 (0.001)
Tb.N	Age, sex, BMI, HKA angle	0.407 (< 0.001)	0.193 (< 0.001)
Tb.Th	Age, sex, BMI	0.103 (0.062)
Tb.Th	Age, sex, BMI, HKA angle	0.349 (< 0.001)	0.246 (< 0.001)
Tb.Sp	Age, sex, BMI	0.176 (0.004)
Tb.Sp	Age, sex, BMI, HKA angle	0.407 (< 0.001)	0.231 (< 0.001)
BS/BV	Age, sex, BMI	0.174 (0.005)
BS/BV	Age, sex, BMI, HKA angle	0.543 (< 0.001)	0.369 (< 0.001)
Lateral
BV/TV	Age, sex, BMI	0.108 (0.014)
BV/TV	Age, sex, BMI, HKA angle	0.491 (< 0.001)	0.345 (< 0.001)
Tb.N	Age, sex, BMI	0.121 (0.034)
Tb.N	Age, sex, BMI, HKA angle	0.349 (< 0.001)	0.228 (< 0.001)
Tb.Th	Age, sex, BMI	0.092 (0.089)
Tb.Th	Age, sex, BMI, HKA angle	0.335 (< 0.001)	0.243 (< 0.001)
Tb.Sp	Age, sex, BMI	0.177 (0.004)
Tb.Sp	Age, sex, BMI, HKA angle	0.366 (< 0.001)	0.189 (< 0.001)
BS/BV	Age, sex, BMI	0.102 (0.064)
BS/BV	Age, sex, BMI, HKA angle	0.374 (< 0.001)	0.272 (< 0.001)

Significant values are in bold
BMI body mass index, BV/TV bone volume fraction, Tb.N trabecular number, Tb.Th trabecular thickness, Tb.Sp trabecular separation, BS/BV specific bone surface

ISSN: 1478-6362