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Table 2 Comparison of patient characteristics according to the development of cardiovascular events during follow-up

From: Disease-specific factors associated with cardiovascular events in patients with Takayasu arteritis

  CV events not occurred (N = 166) CV events occurred (N = 41) P value
Age, years, mean (±SD) 38.5 ± 13.4 43.6 ± 11.8 0.028
Female sex, n (%) 138 (83.1) 36 (87.8) 0.464
Hypertension, n (%) 75 (45.2) 25 (61.0) 0.070
Use of antihypertensive drugs, n (%) 75 (45.2) 25 (61.0) 0.070
Systolic BP, mmHg, mean (± SD) 128.9 ± 15.8 130.9 ± 17.0 0.477
Diastolic BP, mmHg, mean (± SD) 75.2 ± 12.5 76.9 ± 13.2 0.439
Diabetes mellitus, n (%) 11 (6.6) 8 (19.5) 0.029
Smoking, n (%) 12 (7.2) 6 (14.6) 0.210
Total cholesterol, mg/dl, mean (± SD) 182.9 ± 40.4 172.9 ± 42.6 0.167
Triglycerides, mg/dl, mean (± SD) 108.6 ± 57.8 127.6 ± 91.1 0.209
HDL cholesterol, mg/dl, mean (± SD) 57.3 ± 17.1 51.2 ± 15.7 0.040
LDL cholesterol, mg/dl, mean (± SD) 103.8 ± 32.4 96.2 ± 33.8 0.183
Framingham risk score, %, median (IQR)a 3.9 (2.4–7.1) 5.5 (2.9–9.7) 0.119
BMI, kg/m2, mean (± SD) 22.5 ± 3.3 22.7 ± 2.7 0.702
Hemoglobin, g/dl, mean (± SD) 12.3 ± 1.5 12.3 ± 1.3 0.980
Anemia, n (%) 66 (39.8) 18 (43.9) 0.629
ESR, mm/h, median (IQR) 39.0 (20.5–68.5) 41.0 (20.0–66.3) 0.717
CRP, mg/l, median (IQR) 4.1 (1.0–23.1) 3.6 (1.0–15.2) 0.908
Type of vascular involvement, n (%)
 I 42 (25.3) 6 (14.6) 0.147
 IIA 19 (11.4) 4 (9.8) > 0.999
 IIB 32 (19.3) 4 (9.8) 0.150
 III 7 (4.2) 1 (1.6) > 0.999
 IV 11 (6.6) 0 (0.0) 0.126
 V 55 (33.1) 26 (63.4) < 0.001
Pulmonary artery involvement, n (%) 13 (7.8) 3 (7.3) > 0.999
Aortic regurgitation, n (%) 44 (26.5) 17 (41.5) 0.060
Use of glucocorticoids, n (%)
 None-to-low dose 66 (39.8) 19 (46.3) 0.443
 Medium-to-high dose 100 (60.2) 22 (53.7)
Use of MTX, n (%) 108 (65.1) 18 (43.9) 0.013
Use of AZA, n (%) 33 (19.9) 5 (12.2) 0.255
Use of aspirin, n (%) 94 (56.6) 29 (70.7) 0.100
Use of statins, n (%) 97 (58.4) 26 (63.4) 0.561
  1. CV cardiovascular, BP blood pressure, HDL high-density lipoprotein, LDL low-density lipoprotein, BMI body mass index, ESR erythrocyte sedimentation rate, CRP C-reactive protein, MTX methotrexate, AZA azathioprine, SD standard deviation, IQR interquartile range
  2. aPatients aged < 30 years were excluded as per the formula of calculation