From: Disease-specific factors associated with cardiovascular events in patients with Takayasu arteritis
CV events not occurred (N = 166) | CV events occurred (N = 41) | P value | |
---|---|---|---|
Age, years, mean (±SD) | 38.5 ± 13.4 | 43.6 ± 11.8 | 0.028 |
Female sex, n (%) | 138 (83.1) | 36 (87.8) | 0.464 |
Hypertension, n (%) | 75 (45.2) | 25 (61.0) | 0.070 |
Use of antihypertensive drugs, n (%) | 75 (45.2) | 25 (61.0) | 0.070 |
Systolic BP, mmHg, mean (± SD) | 128.9 ± 15.8 | 130.9 ± 17.0 | 0.477 |
Diastolic BP, mmHg, mean (± SD) | 75.2 ± 12.5 | 76.9 ± 13.2 | 0.439 |
Diabetes mellitus, n (%) | 11 (6.6) | 8 (19.5) | 0.029 |
Smoking, n (%) | 12 (7.2) | 6 (14.6) | 0.210 |
Total cholesterol, mg/dl, mean (± SD) | 182.9 ± 40.4 | 172.9 ± 42.6 | 0.167 |
Triglycerides, mg/dl, mean (± SD) | 108.6 ± 57.8 | 127.6 ± 91.1 | 0.209 |
HDL cholesterol, mg/dl, mean (± SD) | 57.3 ± 17.1 | 51.2 ± 15.7 | 0.040 |
LDL cholesterol, mg/dl, mean (± SD) | 103.8 ± 32.4 | 96.2 ± 33.8 | 0.183 |
Framingham risk score, %, median (IQR)a | 3.9 (2.4–7.1) | 5.5 (2.9–9.7) | 0.119 |
BMI, kg/m2, mean (± SD) | 22.5 ± 3.3 | 22.7 ± 2.7 | 0.702 |
Hemoglobin, g/dl, mean (± SD) | 12.3 ± 1.5 | 12.3 ± 1.3 | 0.980 |
Anemia, n (%) | 66 (39.8) | 18 (43.9) | 0.629 |
ESR, mm/h, median (IQR) | 39.0 (20.5–68.5) | 41.0 (20.0–66.3) | 0.717 |
CRP, mg/l, median (IQR) | 4.1 (1.0–23.1) | 3.6 (1.0–15.2) | 0.908 |
Type of vascular involvement, n (%) | |||
I | 42 (25.3) | 6 (14.6) | 0.147 |
IIA | 19 (11.4) | 4 (9.8) | > 0.999 |
IIB | 32 (19.3) | 4 (9.8) | 0.150 |
III | 7 (4.2) | 1 (1.6) | > 0.999 |
IV | 11 (6.6) | 0 (0.0) | 0.126 |
V | 55 (33.1) | 26 (63.4) | < 0.001 |
Pulmonary artery involvement, n (%) | 13 (7.8) | 3 (7.3) | > 0.999 |
Aortic regurgitation, n (%) | 44 (26.5) | 17 (41.5) | 0.060 |
Use of glucocorticoids, n (%) | |||
None-to-low dose | 66 (39.8) | 19 (46.3) | 0.443 |
Medium-to-high dose | 100 (60.2) | 22 (53.7) | |
Use of MTX, n (%) | 108 (65.1) | 18 (43.9) | 0.013 |
Use of AZA, n (%) | 33 (19.9) | 5 (12.2) | 0.255 |
Use of aspirin, n (%) | 94 (56.6) | 29 (70.7) | 0.100 |
Use of statins, n (%) | 97 (58.4) | 26 (63.4) | 0.561 |