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Table 3 Risk of cardiovascular disease according to TAK disease-specific factors

From: Disease-specific factors associated with cardiovascular events in patients with Takayasu arteritis

  Univariable analysis Multivariable analysisa
Unadjusted HR (95% CI) P value Adjusted HR (95% CI) P value
BMI 1.031 (0.926–1.146) 0.579 0.905 (0.796–1.029) 0.129
Anemia 0.880 (0.468–1.654) 0.691 0.924 (0.464–1.838) 0.821
ESR 1.001 (0.991–1.011) 0.878 0.996 (0.985–1.008) 0.551
CRP 0.995 (0.986–1.005) 0.326 0.993 (0.982–1.003) 0.183
Vascular involvement type
 Types other than V 1.000 (reference)   1.000 (reference)  
 Type V 2.741 (1.443–5.205) 0.002 2.852 (1.474–5.518) 0.002
Pulmonary artery involvement 1.011 (0.311–3.288) 0.985 0.717 (0.193–2.655) 0.618
Aortic regurgitation 1.341 (0.703–2.558) 0.373 1.024 (0.505–2.077) 0.947
Use of glucocorticoids
 None-to-low dose 1.000 (reference)   1.000 (reference)  
 Medium-to-high dose 0.780 (0.414–1.471) 0.443 1.030 (0.523–2.030) 0.932
Use of MTX 0.474 (0.253–0.887) 0.020 0.515 (0.268–0.993) 0.047
Use of AZA 0.592 (0.231–1.513) 0.273 0.768 (0.278–2.122) 0.611
Use of aspirin 1.763 (0.880–3.532) 0.110 1.426 (0.695–2.925) 0.333
Use of statins 1.220 (0.640–2.327) 0.546 0.789 (0.391–1.592) 0.508
  1. TAK Takayasu arteritis, HR hazard ratio, CI confidence interval, BMI body mass index, ESR erythrocyte sedimentation rate, CRP C-reactive protein, MTX methotrexate, AZA azathioprine
  2. aAdjusted for traditional cardiovascular risk factors (age, sex, systolic BP, use of antihypertensive drugs, total cholesterol, HDL cholesterol, diabetes mellitus, and smoking status)