Meta-analysis of genome-wide association study identifies FBN2 as a novel locus associated with systemic lupus erythematosus in Thai population

Table 2 List of significant variants at individual locus from the meta-analysis

HAP^a	dbSNP^b	CHR^c	BP^d	RA^e	MAF affected	MAF unaffected	Locus	Locus upstream	Locus downstream	Discovery dataset		Replication dataset		Meta-analysis		p_het^f
HAP^a	dbSNP^b	CHR^c	BP^d	RA^e	MAF affected	MAF unaffected	Locus	Locus upstream	Locus downstream	OR (95% CI)	p	OR (95% CI)	p	OR	p	p_het^f
q32.3	rs7574865	2	191,099,907	A	0.47	0.36	STAT4			1.54 (1.33–1.79)	1.45E−08	1.61 (1.37–1.89)	7.45E−09	1.57	8.218E−16	0.69
q23.3	rs74989671	5	128,398,268	G	0.16	0.11	FBN2			1.52 (1.24–1.86)	4.31E−05	1.58 (1.26–1.98)	7.61E−05	1.54	1.611E−08	0.81
p21.32	rs9270970	6	32,605,797	G	0.42	0.30		HLA-DRB1	HLA-DQA1	2.02 (1.73–2.35)	8.71E−20	1.63 (1.39–1.93)	4.15E−09	1.83	3.617E−26	0.07
q11.23	rs73366469	7	74,619,286	G	0.14	0.09		RP5-1186P10.2	GTF2I	1.8 (1.45–2.24)	1.09E−07	1.65 (1.3–2.1)	2.84E−05	1.73	2.42E−11	0.61
p23.1	rs13277113	8	11,491,677	G	0.26	0.32		FAM167A	BLK	0.64 (0.54–0.76)	2.16E−07	0.74 (0.61–0.88)	8.76E−04	0.68	1.58E−09	0.27
q24.33	rs1385374	12	128,816,149	A	0.20	0.15	SLC15A4			1.54 (1.28–1.85)	5.76E−06	1.37 (1.12–1.69)	2.36E−03	1.46	7.62E−08	0.43
p11.2	rs1143679	16	31,265,490	A	0.07	0.03	ITGAM			1.67 (1.21–2.28)	1.39E−03	2.27 (1.6–3.23)	2.55E−06	1.91	5.81E-08	0.2

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