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Table 2 List of significant variants at individual locus from the meta-analysis

From: Meta-analysis of genome-wide association study identifies FBN2 as a novel locus associated with systemic lupus erythematosus in Thai population

HAPa dbSNPb CHRc BPd RAe MAF affected MAF unaffected Locus Locus upstream Locus downstream Discovery dataset Replication dataset Meta-analysis phetf
OR (95% CI) p OR (95% CI) p OR p
q32.3 rs7574865 2 191,099,907 A 0.47 0.36 STAT4    1.54 (1.33–1.79) 1.45E−08 1.61 (1.37–1.89) 7.45E−09 1.57 8.218E−16 0.69
q23.3 rs74989671 5 128,398,268 G 0.16 0.11 FBN2    1.52 (1.24–1.86) 4.31E−05 1.58 (1.26–1.98) 7.61E−05 1.54 1.611E−08 0.81
p21.32 rs9270970 6 32,605,797 G 0.42 0.30   HLA-DRB1 HLA-DQA1 2.02 (1.73–2.35) 8.71E−20 1.63 (1.39–1.93) 4.15E−09 1.83 3.617E−26 0.07
q11.23 rs73366469 7 74,619,286 G 0.14 0.09   RP5-1186P10.2 GTF2I 1.8 (1.45–2.24) 1.09E−07 1.65 (1.3–2.1) 2.84E−05 1.73 2.42E−11 0.61
p23.1 rs13277113 8 11,491,677 G 0.26 0.32   FAM167A BLK 0.64 (0.54–0.76) 2.16E−07 0.74 (0.61–0.88) 8.76E−04 0.68 1.58E−09 0.27
q24.33 rs1385374 12 128,816,149 A 0.20 0.15 SLC15A4    1.54 (1.28–1.85) 5.76E−06 1.37 (1.12–1.69) 2.36E−03 1.46 7.62E−08 0.43
p11.2 rs1143679 16 31,265,490 A 0.07 0.03 ITGAM    1.67 (1.21–2.28) 1.39E−03 2.27 (1.6–3.23) 2.55E−06 1.91 5.81E-08 0.2
  1. aHaplotype
  2. bdbSNP from single nucleotide polymorphisms database (NCBI)
  3. cChromosome
  4. dPosition
  5. eRisk alleles
  6. fp value of heterogeneity