Skip to main content

Table 2 Overview of A20-related mouse models

From: A20: a master regulator of arthritis

Genotype

Domain

Alteration

Phenotype

References

A20−/−

Full knock out

Full knock out

Severe inflammation, cachexia, and premature deaths

Lee at al. 2000 [104]

A20myel-KO

Myeloid-specific

Exon IV and V

Chronic inflammation in ankles, tibiotalar joints and tarsal joints, massive cartilage and bone destruction

Mammati et al. 2011 [21]

A20mZnF7/mZnF7

ZnF7

C764A/C767A

Inflammatory arthritis with splenomegaly, symmetrical swelling joints

Polykratis et al. 2019 [29]

A20ZF7-CC

ZnF7

C764A/C767A

Psoriasis and psoriatic arthritis

Razani et al. 2020 [28]

A20ZF4ZF7

ZnF4 and ZnF7

C609A/C612A

Perinatal lethality, multiorgan inflammation, tissue damage

Razani et al. 2020 [28]

C764A/C767A

A20ZF4ZF7

ZnF4 and ZnF7

C609A/C612A

Polyarthritis-like manifestations

Razani et al. 2020 [28]

Myeloid-specific

C764A/C767A

Tnfaip3OTU

OTU

C103A

Splenomegaly, ↑IL-1 in response to oral dextran sulfate sodium, ↑IL-6, ↑NF-κB signaling

Lu et al. 2013 [13]

Tnfaip3ZF4

ZnF4

C609A/C613A

Lu et al. 2013 [13]

A20C103A

OTU

C103A

Grossly normal without inflammation

De et al. 2014 [15]

Tnfaip3otu/otu

OTU

C103A

Sensitive to TNF, LPS, ↑MOG-EAE

Wertz et al. 2015 [23]

Tnfaip3z4Cys/z4Cys

ZnF4

C609A/C612A

Sensitive to TNF, ↑MOG-EAE

Wertz et al. 2015 [23]

Tnfaip3z4Ub/z4Ub

ZnF4

Y599A/F600A

Sensitive to TNF

Wertz et al. 2015 [23]

Tnfaip31325N

OTU

I325N

Mild inflammation in pancreatic islets

Zammit et al. 2019 [105]

Tnfaip3C243Y

OTU

C243Y

Spontaneous inflammatory pathology

Zammit et al. 2019 [105]

Tnfaip31207L

OTU

T108A/I207L

Healthy

Zammit et al. 2019 [105]

A20F

B cell-specific

Exon IV and V

↑IL-6, ↑B cell proliferation

Chu et al. 2011 [106]

Chronic inflammation in younger mice and autoimmune syndrome in older mice

A20GFP

CD4 T cell-specific

Exon IV and V

No spontaneous phenotype

Drennan et al. 2016 [107]

↓invariant NKT cells

DC ACT

CD11c-specific

 

↑inflammatory mediators in kidney

Lu et al. 2019 [108]

  1. OTU ovarian tumor, MOG-EAE myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis, DC ACT Cd11c-Cre+A20flox/wt.