Genotype | Domain | Alteration | Phenotype | References |
---|---|---|---|---|
A20−/− | Full knock out | Full knock out | Severe inflammation, cachexia, and premature deaths | Lee at al. 2000 [104] |
A20myel-KO | Myeloid-specific | Exon IV and V | Chronic inflammation in ankles, tibiotalar joints and tarsal joints, massive cartilage and bone destruction | Mammati et al. 2011 [21] |
A20mZnF7/mZnF7 | ZnF7 | C764A/C767A | Inflammatory arthritis with splenomegaly, symmetrical swelling joints | Polykratis et al. 2019 [29] |
A20ZF7-CC | ZnF7 | C764A/C767A | Psoriasis and psoriatic arthritis | Razani et al. 2020 [28] |
A20ZF4ZF7 | ZnF4 and ZnF7 | C609A/C612A | Perinatal lethality, multiorgan inflammation, tissue damage | Razani et al. 2020 [28] |
C764A/C767A | ||||
A20ZF4ZF7 | ZnF4 and ZnF7 | C609A/C612A | Polyarthritis-like manifestations | Razani et al. 2020 [28] |
Myeloid-specific | C764A/C767A | |||
Tnfaip3OTU | OTU | C103A | Splenomegaly, ↑IL-1 in response to oral dextran sulfate sodium, ↑IL-6, ↑NF-κB signaling | Lu et al. 2013 [13] |
Tnfaip3ZF4 | ZnF4 | C609A/C613A | Lu et al. 2013 [13] | |
A20C103A | OTU | C103A | Grossly normal without inflammation | De et al. 2014 [15] |
Tnfaip3otu/otu | OTU | C103A | Sensitive to TNF, LPS, ↑MOG-EAE | Wertz et al. 2015 [23] |
Tnfaip3z4Cys/z4Cys | ZnF4 | C609A/C612A | Sensitive to TNF, ↑MOG-EAE | Wertz et al. 2015 [23] |
Tnfaip3z4Ub/z4Ub | ZnF4 | Y599A/F600A | Sensitive to TNF | Wertz et al. 2015 [23] |
Tnfaip31325N | OTU | I325N | Mild inflammation in pancreatic islets | Zammit et al. 2019 [105] |
Tnfaip3C243Y | OTU | C243Y | Spontaneous inflammatory pathology | Zammit et al. 2019 [105] |
Tnfaip31207L | OTU | T108A/I207L | Healthy | Zammit et al. 2019 [105] |
A20F | B cell-specific | Exon IV and V | ↑IL-6, ↑B cell proliferation | Chu et al. 2011 [106] |
Chronic inflammation in younger mice and autoimmune syndrome in older mice | ||||
A20GFP | CD4 T cell-specific | Exon IV and V | No spontaneous phenotype | Drennan et al. 2016 [107] |
↓invariant NKT cells | ||||
DC ACT | CD11c-specific |  | ↑inflammatory mediators in kidney | Lu et al. 2019 [108] |