MMRM variable | Anti-CarbV antibody isotypes | Anti-MCV antibody isotypes | ||||
---|---|---|---|---|---|---|
IgA | IgG | IgM | IgA | IgG | IgM | |
Time | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Treatment | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Baseline antibody (only in MMRM with linear association) | NA | 0.033 | 0.981 | NA | NA | NA |
Baseline antibody NCS (in MMRM with nonlinear association) | 0.002 | NA | NA | 0.323 | 0.503 | 0.036 |
Baseline SDAI | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Baseline ACPA | 0.702 | 0.759 | 0.957 | 0.912 | 0.863 | 0.980 |
Baseline RF | 0.120 | 0.123 | 0.965 | 0.109 | 0.155 | 0.132 |
Erosions | 0.301 | 0.447 | 0.375 | 0.317 | 0.302 | 0.318 |
Age | 0.410 | 0.378 | 0.430 | 0.365 | 0.372 | 0.168 |
Sex | 0.826 | 0.753 | 0.870 | 0.839 | 0.749 | 0.656 |
BMI | 0.763 | 0.881 | 0.716 | 0.830 | 0.860 | 0.873 |
Geographic region | 0.020 | 0.045 | 0.071 | 0.056 | 0.053 | 0.057 |
Time-by-treatment interaction | 0.633 | 0.633 | 0.633 | 0.633 | 0.633 | 0.633 |
Baseline antibody-by-treatment interaction | NA | NA | < 0.001 | NA | NA | NA |