AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year—a retrospective cohort study with 522 cases

Table 3 COX univariate analysis

Variables	Readmission within 1 year		Need for MV within 1 year		Deaths within 1 year
Variables	p value	HR	p value	HR	p value	HR
Sex	0.249		0.530		0.700
Age, years	0.077		0.042		0.017
≤ 40
40–60 (1)
> 60 (2)
Diagnosis	0.028		0.035		0.093
DM
ADM (1)
PM (2)
OLS	0.102		0.148		0.078
Comorbidities
Diabetes mellitus	0.322		0.395		0.608
Hypertension	0.353		0.785		0.801
Chronic hepatitis B	0.233		0.337		0.998
HB	0.519		0.062		0.386
PLT	0.419		0.598		0.377
WBC	0.05		0.631		0.962
EO%	0.017		0.001		0.017
NLR	0.514		< 0.001		< 0.001
ALB	0.842		< 0.001		< 0.001
UA/CREA	0.669		0.003		0.013
AST/ALT	0.003		0.005		< 0.001
≤ 0.91	Reference		Reference		Reference
0.91–1.26 (1)	0.225	1.454	0.781	0.857	0.657	1.221
1.26–1.73 (2)	0.329	1.346	0.469	1.429	0.302	1.554
> 1.73 (3)	0.001	2.664	0.008	3.195	0.001	3.668
TG	0.011		0.049		< 0.001
LDL	0.152		0.029		0.149
CK	0.096		0.082		0.086

Bold indicates p < 0.1
DM dermatomyosis, CADM clinically asymptomatic dermatomyosis, PM polymyosis, OLS overlap syndrome, MDA5 anti-melanoma differentiation-associated gene 5, HB hemoglobin, PLT platelet count, WBC white blood cell count, EO% percentage of eosinophils, NLR neutrophil/lymphocyte ratio, ALB albumin, UA uric acid, CREA creatinine, TG triglycerides, LDL low-density lipoprotein, CK creatine kinase, MV mechanical ventilation

ISSN: 1478-6362