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Table 4 Cox multivariate regression analysis across quartiles of AST/ALT ratio

From: AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year—a retrospective cohort study with 522 cases

AST/ALT ratio N (%) Unadjusted HR (95%CI) p value Adjusted HR (95%CI) p value
Mortality*
 ≤ 0.91 9 (14.1) Reference
 0.91–1.26 11 (17.2) 1.221 (0.506–2.947) 0.657 1.259 (0.514–3.086) 0.614
 1.26–1.73 14 (21.9) 1.554 (0.673–3.590) 0.302 1.814 (0.757–4.35) 0.182
 > 1.73 30 (46.9) 3.668 (1.741–7.729) 0.001 3.423 (1.481–7.911) 0.004
Mechanical ventilation**
 ≤ 0.91 7 (16.3) Reference
 0.91–1.26 6 (14) 0.857 (0.288–2.550) 0.781 1.086 (0.356–3.312) 0.884
 1.26–1.73 10 (23.3) 1.429 (0.544–3.756) 0.469 2.231 (0.791–6.294) 0.129
 > 1.73 20 (46.5) 3.195 (1.350–7.559) 0.008 4.172 (1.498–11.621) 0.006
Readmission***
 ≤ 0.91 19 (18.4) Reference
 0.91–1.26 25 (24.3) 1.454 (0.794–2.662) 0.225 1.62 (0.879–3.066) 0.120
 1.26–1.73 26 (25.2) 1.346 (0.741–2.446) 0.329 1.935 (1.020–3.673) 0.043
 > 1.73 33 (32) 2.664 (1.513–4.692) 0.001 3.670 (1.968–6.844) < 0.001
  1. Bold indicates statistical significance
  2. N number, HR hazard ratio, CI confidence interval, AST aspartate transaminase, ALT alanine transaminase
  3. *HRs were adjusted by sex, age, diagnosis, OLS, EO%, NLR, ALB, UA/CREA, TG, and CK
  4. **HRs were adjusted by sex, age, diagnosis, HB, EO%, NLR, ALB, UA/CREA, TG, LDL, and CK
  5. ***HRs were adjusted by sex, age, diagnosis, WBC, EO%, TG, and CK