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Table 4 Cox multivariate regression analysis across quartiles of AST/ALT ratio

From: AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year—a retrospective cohort study with 522 cases

AST/ALT ratio

N (%)

Unadjusted HR (95%CI)

p value

Adjusted HR (95%CI)

p value

Mortality*

 ≤ 0.91

9 (14.1)

Reference

 0.91–1.26

11 (17.2)

1.221 (0.506–2.947)

0.657

1.259 (0.514–3.086)

0.614

 1.26–1.73

14 (21.9)

1.554 (0.673–3.590)

0.302

1.814 (0.757–4.35)

0.182

 > 1.73

30 (46.9)

3.668 (1.741–7.729)

0.001

3.423 (1.481–7.911)

0.004

Mechanical ventilation**

 ≤ 0.91

7 (16.3)

Reference

 0.91–1.26

6 (14)

0.857 (0.288–2.550)

0.781

1.086 (0.356–3.312)

0.884

 1.26–1.73

10 (23.3)

1.429 (0.544–3.756)

0.469

2.231 (0.791–6.294)

0.129

 > 1.73

20 (46.5)

3.195 (1.350–7.559)

0.008

4.172 (1.498–11.621)

0.006

Readmission***

 ≤ 0.91

19 (18.4)

Reference

 0.91–1.26

25 (24.3)

1.454 (0.794–2.662)

0.225

1.62 (0.879–3.066)

0.120

 1.26–1.73

26 (25.2)

1.346 (0.741–2.446)

0.329

1.935 (1.020–3.673)

0.043

 > 1.73

33 (32)

2.664 (1.513–4.692)

0.001

3.670 (1.968–6.844)

< 0.001

  1. Bold indicates statistical significance
  2. N number, HR hazard ratio, CI confidence interval, AST aspartate transaminase, ALT alanine transaminase
  3. *HRs were adjusted by sex, age, diagnosis, OLS, EO%, NLR, ALB, UA/CREA, TG, and CK
  4. **HRs were adjusted by sex, age, diagnosis, HB, EO%, NLR, ALB, UA/CREA, TG, LDL, and CK
  5. ***HRs were adjusted by sex, age, diagnosis, WBC, EO%, TG, and CK