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Table 1 Efficacy of the first and second TNFi (adjusted models)

From: Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis: is the reason to switch relevant?

 

1st TNF % (95% CI)

2nd TNF % (95% CI)

Outcome at 3 M defined (n = 96*)

ASDAS CII

51 (42; 60)

41 (31; 50)

BASDAI50

45 (36; 54)

39 (29; 48)

ASDAS MII

33 (25; 42)

13 (6; 19)

ASDAS LDA

42 (32; 51)

26 (18; 35)

ASDAS inactive

19 (12; 26)

16 (9; 22)

Outcome at 6 M defined (n = 79*)

ASDAS CII

56 (46; 66)

35 (26; 45)

BASDAI50

46 (35; 56)

33 (23; 43)

ASDAS MII

32 (22; 41)

22 (13; 30)

ASDAS LDA

41 (30; 51)

29 (19; 39)

ASDAS inactive

11 (5; 18)

15 (8; 22)

  1. Percentages and 95% CI are derived from logistic regression models adjusted for age, gender, and CRP at baseline
  2. ASDAS Ankylosing Spondylitis Disease Activity Score, BASDAI Bath Ankylosing Spondylitis Activity Index, LDA low disease activity, ID inactive disease, CII clinically important improvement, MII major important improvement, BASDAI50 Bath Ankylosing Spondylitis Disease Activity Index 50, TNFi tumor necrosis factor inhibitor, M months
  3. *96 patients had ASDAS and BASDAI outcomes available at baseline and 3 months for both TNFi; 79 patients had ASDAS and BASDAI outcomes available at baseline and 6 months for both TNFi