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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis

Fig. 1

S100A8 and S100A9 expression is increased during SCW arthritis. a In synovial washouts, S100A8/9 was detected using an ELISA. Washouts were obtained by washing synovial explants for 2 h in the culture medium at RT. Explants were isolated at baseline and at days 1, 2, and 7 (b). Using immunohistochemistry, S100A8 and S100A9 (c) were detected in the knee joints at baseline and at days 1, 2, and 7 after induction of synovitis. S100A8/9 is clearly increased at days 1 and 2 and wanes thereafter (n = 6 for all groups). d This is quantified using ImageJ. One-way ANOVA with Tukey multiple comparison test was performed. ***p < 0.001; **p < 0.01; *p < 0.05. P, patella; F, femur; S, synovium

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