Fig. 4
From: The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis
Allodynia is induced during SCW synovitis, but not different between WT and S100A9−/−. Injection of saline did not induce changes in the pain threshold, but injection of SCW lowered the threshold significantly at day 1 (a). Although the threshold recovered partly at day 7, it was still significantly different from baseline. Allodynia in S100a9−/− mice did not differ from WT and showed a highly similar pattern, indicating that S100A8/9 is not involved in sensitization. Significance was tested using a two-way ANOVA at n = 8 per group. A Tukey post hoc test was performed to identify significantly different means (*p < 0.05; **p < 0.01; ***p < 0.001)