Table 2 The area under the receiver operating characteristic curves (AUC) of inflammatory PBL gene expression biomarkers to radiographic fast progressors of JSN (> 0.5 mm) at 24 months in patients with SKOA in NYU extended and OAI cohorts
Fast progressors (JSN > 0.5 mm) vs. non-progressors (JSN ≤ 0.0 mm) | AUC (95% CI) | Adjusted p value for model |
|---|---|---|
NYU (n = 243) | ||
 Age | 0.48 (0.39–0.56) | 0.711 |
 Sex | 0.62 (0.54–0.71) | 0.001 |
 BMI | 0.61 (0.53–0.69) | 0.004 |
 Age + sex + BMI (ASB) | 0.65 (0.57–0.73) | < 0.0001 |
 IL-1β | 0.62 (0.53–0.70) | 0.003 |
 COX-2 | 0.68 (0.60–0.75) | < 0.0001 |
 TNFα | 0.66 (0.57–0.74) | < 0.0001 |
 IL-1β + COX-2 + TNFα | 0.60 (0.5 2–0.69) | 0.008 |
 IL-1β + ASB | 0.65 (0.57–0.73) | < 0.0001 |
 COX-2 + ASB | 0.66 (0.58–0.74) | < 0.0001 |
 TNFα + ASB | 0.64 (0.56–0.72) | < 0.0001 |
 IL-1β + COX-2 + TNFα + ASB | 0.66 (0.58–0.74) | < 0.0001 |
OAI (n = 203) | ||
 Age | 0.38 (0.27–0.49) | 0.987 |
 Sex | 0.50 (0.39–0.61) | 0.482 |
 BMI | 0.38 (0.27–0.48) | 0.989 |
 Age + sex + BMI (ASB) | 0.36 (0.26–0.47) | 0.995 |
 IL-1β | 0.76 (0.66–0.85) | < 0.0001 |
 COX-2 | 0.64 (0.53–0.75) | 0.006 |
 TNFα | 0.68 (0.58–0.79) | < 0.0001 |
 IL-1β + COX-2 + TNFα | 0.69 (0.59–0.79) | < 0.0001 |
 IL-1β + ASB | 0.63 (0.53–0.73) | 0.007 |
 COX-2 + ASB | 0.50 (0.38–0.61) | 0.513 |
 TNFα + ASB | 0.56 (0.45–0.67) | 0.158 |
 IL-1β + COX-2 + TNFα + ASB | 0.59 (0.48–0.69) | 0.063 |
NYU + OAI combined (n = 436) | ||
 Age | 0.47 (0.40–0.54) | 0.822 |
 Sex | 0.56 (0.49–0.63) | 0.039 |
 BMI | 0.57 (0.50–0.64) | 0.021 |
 Age + sex + BMI (ASB) | 0.57 (0.50–0.63) | 0.019 |
 IL-1β | 0.66 (0.60–0.72) | < 0.0001 |
 COX-2 | 0.66 (0.59–0.72) | < 0.0001 |
 TNFα | 0.67 (0.60–0.73) | < 0.0001 |
 IL-1β + COX-2 + TNFα | 0.63 (0.57–0.70) | < 0.0001 |
 IL-1β + ASB | 0.60 (0.54–0.67) | 0.001 |
 COX-2 + ASB | 0.59 (0.53–0.66) | 0.003 |
 TNFα + ASB | 0.57 (0.50–0.64) | 0.019 |
 IL-1β + COX-2 + TNFα + ASB | 0.61 (0.54–0.68) | 0.001 |