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Table 2 The area under the receiver operating characteristic curves (AUC) of inflammatory PBL gene expression biomarkers to radiographic fast progressors of JSN (> 0.5 mm) at 24 months in patients with SKOA in NYU extended and OAI cohorts

From: The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis

Fast progressors (JSN > 0.5 mm) vs. non-progressors (JSN ≤ 0.0 mm) AUC (95% CI) Adjusted p value for model
NYU (n = 243)
 Age 0.48 (0.39–0.56) 0.711
 Sex 0.62 (0.54–0.71) 0.001
 BMI 0.61 (0.53–0.69) 0.004
 Age + sex + BMI (ASB) 0.65 (0.57–0.73) < 0.0001
 IL-1β 0.62 (0.53–0.70) 0.003
 COX-2 0.68 (0.60–0.75) < 0.0001
 TNFα 0.66 (0.57–0.74) < 0.0001
 IL-1β + COX-2 + TNFα 0.60 (0.5 2–0.69) 0.008
 IL-1β + ASB 0.65 (0.57–0.73) < 0.0001
 COX-2 + ASB 0.66 (0.58–0.74) < 0.0001
 TNFα + ASB 0.64 (0.56–0.72) < 0.0001
 IL-1β + COX-2 + TNFα + ASB 0.66 (0.58–0.74) < 0.0001
OAI (n = 203)
 Age 0.38 (0.27–0.49) 0.987
 Sex 0.50 (0.39–0.61) 0.482
 BMI 0.38 (0.27–0.48) 0.989
 Age + sex + BMI (ASB) 0.36 (0.26–0.47) 0.995
 IL-1β 0.76 (0.66–0.85) < 0.0001
 COX-2 0.64 (0.53–0.75) 0.006
 TNFα 0.68 (0.58–0.79) < 0.0001
 IL-1β + COX-2 + TNFα 0.69 (0.59–0.79) < 0.0001
 IL-1β + ASB 0.63 (0.53–0.73) 0.007
 COX-2 + ASB 0.50 (0.38–0.61) 0.513
 TNFα + ASB 0.56 (0.45–0.67) 0.158
 IL-1β + COX-2 + TNFα + ASB 0.59 (0.48–0.69) 0.063
NYU + OAI combined (n = 436)
 Age 0.47 (0.40–0.54) 0.822
 Sex 0.56 (0.49–0.63) 0.039
 BMI 0.57 (0.50–0.64) 0.021
 Age + sex + BMI (ASB) 0.57 (0.50–0.63) 0.019
 IL-1β 0.66 (0.60–0.72) < 0.0001
 COX-2 0.66 (0.59–0.72) < 0.0001
 TNFα 0.67 (0.60–0.73) < 0.0001
 IL-1β + COX-2 + TNFα 0.63 (0.57–0.70) < 0.0001
 IL-1β + ASB 0.60 (0.54–0.67) 0.001
 COX-2 + ASB 0.59 (0.53–0.66) 0.003
 TNFα + ASB 0.57 (0.50–0.64) 0.019
 IL-1β + COX-2 + TNFα + ASB 0.61 (0.54–0.68) 0.001
  1. ASB age, sex, and BMI, JSN joint space narrowing, SKOA symptomatic knee OA, AUC area under the (receiver operating characteristic) curve, 95% CI 95% confidence interval; All comparisons are versus non-progressors (JSN ≤ 0 mm). NYU cohort: non-progressors (n = 115) and fast progressors (n = 72); OAI cohort: non-progressors (n = 76) and fast progressors (n = 44)