The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis

Attur, Mukundan; Krasnokutsky, Svetlana; Zhou, Hua; Samuels, Jonathan; Chang, Gregory; Bencardino, Jenny; Rosenthal, Pamela; Rybak, Leon; Huebner, Janet L.; Kraus, Virginia B.; Abramson, Steven B.

doi:10.1186/s13075-020-02298-6

Table 3 Association of baseline MRI-scored medial WORMS variables with clinical and radiographic features at baseline and 24 months—NYU cohort (n = 111)

From: The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis

	Baseline WOMAC pain	Baseline VAS pain	24-month WOMAC pain	24-month VAS pain	Baseline signal KL	24-month signal KL	Delta signal KL	Baseline medial JSW	24-month medial JSW	Medial JSN
Cartilage overall	0.09 (0.34)	0.01 (0.94)	0.07 (0.45)	0.10 (0.29)	0.33 (< 0.01)	0.44 (< 0.01)	0.20(0.03)	− 0.28 (< 0.01)	− 0.34 (< 0.01)	0.13 (0.15)
Cartilage medial overall	0.15 (0.12)	0.12 (0.22)	0.09 (0.34)	0.09 (0.38)	0.36 (< 0.01)	0.44 (< 0.01)	0.14 (0.15)	− 0.32 (< 0.01)	− 0.41 (< 0.01)	0.10 (0.29)
BML overall	0.07 (0.45)	0.09 (0.36)	0.04 (0.66)	0.10 (0.28)	0.31 (< 0.01)	0.35 (< 0.01)	0.05 (0.58)	−0.13 (0.16)	−0.22 (0.02)	0.14 (0.14)
BML medial overall	0.10 (0.30)	0.13 (0.18)	0.04 (0.69)	0.07 (0.48)	0.31 (< 0.01)	0.32 (< 0.01)	−0.003 (0.98)	−0.17 (0.07)	− 0.28 (< 0.01)	0.19 (0.05)
Meniscus overall	0.20 (0.04)	0.15 (0.11)	0.08 (0.38)	0.13 (0.18)	0.30 (< 0.01)	0.41 (< 0.01)	0.16 (0.10)	−0.24 (0.01)	−0.34 (< 0.01)	0.23 (0.02)
Cartilage medial femur central	0.13 (0.17)	0.15 (0.12)	0.02 (0.87)	0.01 (0.90)	0.27 (< 0.01)	0.36 (< 0.01)	0.16 (0.09)	−0.31 (< 0.01)	− 0.40 (< 0.01)	0.08 (0.42)
Cartilage medial femur posterior	0.12 (0.22)	0.08 (0.44)	0.15 (0.13)	0.12 (0.21)	0.34 (< 0.01)	0.42 (< 0.01)	0.13 (0.19)	−0.33 (< 0.01)	− 0.35 (< 0.01)	0.04 (0.67)
Cartilage medial tibial anterior	0.15 (0.13)	0.11 (0.28)	0.09 (0.42)	0.08 (0.44)	0.32 (< 0.01)	0.39 (< 0.01)	0.13 (0.16)	−0.27 (< 0.01)	− 0.32 (< 0.01)	0.03 (0.78)
Cartilage medial tibial central	0.13 (0.17)	0.17 (0.08)	0.11 (0.25)	0.12 (0.20)	0.29 (< 0.01)	0.37 (< 0.01)	0.15 (0.11)	−0.31 (< 0.01)	− 0.41 (< 0.01)	0.12 (0.21)
Cartilage medial tibial posterior	−0.04 (0.68)	− 0.07 (0.50)	− 0.09 (0.38)	−0.06 (0.53)	0.27 (< 0.01)	0.31 (< 0.01)	0.07 (0.48)	−0.08 (0.38)	− 0.19 (0.05)	0.05 (0.61)
BML medial femur central	0.03 (0.77)	0.09 (0.34)	−0.05 (0.63)	0.03 (0.74)	0.17 (0.08)	0.22 (0.02)	0.07 (0.45)	−0.10 (0.28)	−0.21 (0.03)	0.10 (0.30)
BML medial femur posterior	0.06 (0.53)	0.004 (0.96)	0.03 (0.79)	0.10 (0.28)	0.09 (0.35)	0.12 (0.22)	0.03 (0.75)	−0.05 (0.62)	−0.10 (0.29)	0.11 (0.24)
BML medial tibial anterior	0.19 (0.05)	0.18 (0.07)	0.09 (0.38)	0.11 (0.28)	0.04 (0.65)	0.08 (0.43)	0.05 (0.64)	−0.05 (0.61)	−0.19 (0.05)	0.22 (0.02)
BML medial tibial central	0.19 (0.05)	0.15 (0.12)	0.15 (0.13)	0.20 (0.04)	0.21 (0.03)	0.28 (< 0.01)	0.09 (0.35)	−0.22 (0.02)	−0.34 (< 0.01)	0.22 (0.02)
BML medial tibial posterior	−0.04 (0.72)	0.02 (0.80)	−0.05 (0.61)	−0.06 (0.56)	0.11 (0.24)	0.13 (0.16)	0.04 (0.70)	−0.03 (0.73)	0.00 (0.97)	−0.01 (0.94)

Data shown are Spearman correlation coefficients, adjusted for age, sex, and BMI. p values for the correlations are in parentheses. Significant p values are presented in bold font. WORMS Whole-Organ Magnetic Resonance Imaging Score, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index, VAS visual analog scale, KL Kellgren–Lawrence grade, JSW joint space width, JSN joint space narrowing, BML bone marrow lesion

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