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Table 3 Association of baseline MRI-scored medial WORMS variables with clinical and radiographic features at baseline and 24 months—NYU cohort (n = 111)

From: The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis

  Baseline WOMAC pain Baseline VAS
pain
24-month WOMAC pain 24-month VAS
pain
Baseline signal KL 24-month signal KL Delta signal KL Baseline medial JSW 24-month medial JSW Medial JSN
Cartilage overall 0.09 (0.34) 0.01 (0.94) 0.07 (0.45) 0.10 (0.29) 0.33 (< 0.01) 0.44 (< 0.01) 0.20(0.03) − 0.28 (< 0.01) − 0.34 (< 0.01) 0.13 (0.15)
Cartilage medial overall 0.15 (0.12) 0.12 (0.22) 0.09 (0.34) 0.09 (0.38) 0.36 (< 0.01) 0.44 (< 0.01) 0.14 (0.15) − 0.32 (< 0.01) − 0.41 (< 0.01) 0.10 (0.29)
BML overall 0.07 (0.45) 0.09 (0.36) 0.04 (0.66) 0.10 (0.28) 0.31 (< 0.01) 0.35 (< 0.01) 0.05 (0.58) −0.13 (0.16) −0.22 (0.02) 0.14 (0.14)
BML medial overall 0.10 (0.30) 0.13 (0.18) 0.04 (0.69) 0.07 (0.48) 0.31 (< 0.01) 0.32 (< 0.01) −0.003 (0.98) −0.17 (0.07) − 0.28 (< 0.01) 0.19 (0.05)
Meniscus overall 0.20 (0.04) 0.15 (0.11) 0.08 (0.38) 0.13 (0.18) 0.30 (< 0.01) 0.41 (< 0.01) 0.16 (0.10) −0.24 (0.01) −0.34 (< 0.01) 0.23 (0.02)
Cartilage medial femur central 0.13 (0.17) 0.15 (0.12) 0.02 (0.87) 0.01 (0.90) 0.27 (< 0.01) 0.36 (< 0.01) 0.16 (0.09) −0.31 (< 0.01) − 0.40 (< 0.01) 0.08 (0.42)
Cartilage medial femur posterior 0.12 (0.22) 0.08 (0.44) 0.15 (0.13) 0.12 (0.21) 0.34 (< 0.01) 0.42 (< 0.01) 0.13 (0.19) −0.33 (< 0.01) − 0.35 (< 0.01) 0.04 (0.67)
Cartilage medial tibial anterior 0.15 (0.13) 0.11 (0.28) 0.09 (0.42) 0.08 (0.44) 0.32 (< 0.01) 0.39 (< 0.01) 0.13 (0.16) −0.27 (< 0.01) − 0.32 (< 0.01) 0.03 (0.78)
Cartilage medial tibial central 0.13 (0.17) 0.17 (0.08) 0.11 (0.25) 0.12 (0.20) 0.29 (< 0.01) 0.37 (< 0.01) 0.15 (0.11) −0.31 (< 0.01) − 0.41 (< 0.01) 0.12 (0.21)
Cartilage medial tibial posterior −0.04 (0.68) − 0.07 (0.50) − 0.09 (0.38) −0.06 (0.53) 0.27 (< 0.01) 0.31 (< 0.01) 0.07 (0.48) −0.08 (0.38) − 0.19 (0.05) 0.05 (0.61)
BML medial femur central 0.03 (0.77) 0.09 (0.34) −0.05 (0.63) 0.03 (0.74) 0.17 (0.08) 0.22 (0.02) 0.07 (0.45) −0.10 (0.28) −0.21 (0.03) 0.10 (0.30)
BML medial femur posterior 0.06 (0.53) 0.004 (0.96) 0.03 (0.79) 0.10 (0.28) 0.09 (0.35) 0.12 (0.22) 0.03 (0.75) −0.05 (0.62) −0.10 (0.29) 0.11 (0.24)
BML medial tibial anterior 0.19 (0.05) 0.18 (0.07) 0.09 (0.38) 0.11 (0.28) 0.04 (0.65) 0.08 (0.43) 0.05 (0.64) −0.05 (0.61) −0.19 (0.05) 0.22 (0.02)
BML medial tibial central 0.19 (0.05) 0.15 (0.12) 0.15 (0.13) 0.20 (0.04) 0.21 (0.03) 0.28 (< 0.01) 0.09 (0.35) −0.22 (0.02) −0.34 (< 0.01) 0.22 (0.02)
BML medial tibial posterior −0.04 (0.72) 0.02 (0.80) −0.05 (0.61) −0.06 (0.56) 0.11 (0.24) 0.13 (0.16) 0.04 (0.70) −0.03 (0.73) 0.00 (0.97) −0.01 (0.94)
  1. Data shown are Spearman correlation coefficients, adjusted for age, sex, and BMI. p values for the correlations are in parentheses. Significant p values are presented in bold font. WORMS Whole-Organ Magnetic Resonance Imaging Score, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index, VAS visual analog scale, KL Kellgren–Lawrence grade, JSW joint space width, JSN joint space narrowing, BML bone marrow lesion