The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis

Table 4 Baseline cartilage and BML scores in radiographic non-progressors compared to fast progressors in NYU (4A) and OAI (4B) SKOA

A—NYU	Non-progressors JSN ≤ 0 mm (n = 39) Mean (SD)	Fast progressors JSN ≥ 0.5 mm (n = 45) Mean (SD)	p value	FDR
Cartilage medial overall (0–30)	13.88 (8.61)	15.42 (8.71)	0.42	0.42
Cartilage lateral overall (0–30)	3.56 (6.62)	5.24 (7.89)	0.298	0.398
BML medial overall (0–15)	0.59 (1.14)	1.78 (2.22)	0.003	0.014
BML lateral overall (0–15)	0.33 (0.80)	0.16 (0.47)	0.214	0.398
B—OAI	Non-progressors JSN ≤ 0 mm (n = 29) Mean (SD)	Fast progressors JSN ≥ 0.5 mm (n = 34) Mean (SD)	p value	FDR
Cartilage loss medial (0–36)	4.21 (2.90)	7.09 (3.78)	0.006	0.014
Cartilage loss lateral (0–36)	5.04 (4.09)	2.32 (2.80)	0.012	0.025
BML medial overall (0–36)	1.21 (1.82)	3.27 (2.31)	0.002	0.013
BML lateral overall (0–36)	2.23 (2.84)	0.98 (1.50)	0.072	0.102

Abbreviations: WORMS Whole-Organ Magnetic Resonance Imaging Score, BML bone marrow lesion, JSN joint space narrowing, FDR false discovery rate. JSN values are expressed in mm as mean ± standard deviation (SD). All comparisons are versus non-progressors (JSN ≤ 0 mm). Significant p values are represented in bold font

ISSN: 1478-6362