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Table 6 The odds ratios (OR) comparing baseline inflammatory PBL inflammatory gene expression biomarkers and osteophytes with and without medial BML to predict 24-month fast radiographic knee OA progression in the combined NYU and OAI cohorts

From: The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis

Biomarkers   Biomarkers + baseline medial BML
Fast progressors (JSN > 0.5 mm) vs. non-progressors (JSN ≤ 0.0 mm) Odds ratio 95% CI Adjusted p value for model Biomarkers + baseline medial BML Odds ratio 95% CI Adjusted p value for model p value for increase
Age 1 (1.0–1.0) 0.769 Age 2.46 (1.32–4.6) 0.006 0.001
Sex 1 (1.0–1.0) 0.678 Sex 2.29 (1.24–4.23) 0.007 0.002
BMI 1 (1.0–1.0) 0.151 BMI 2.15 (1.17–3.96) 0.006 0.005
COX-2 3.56 (0.92–13.72) 0.019 COX-2 8.64 (1.36–54.84) < 0.0001 < 0.0001
IL-1β 1.90 (0.56–6.41) 0.074 IL-1β 4.09 (0.753–22.230) < 0.0001 < 0.0001
TNFα 1.12 (0.78–1.63) 0.696 TNFα 3.11 (1.19–8.14) < 0.0001 < 0.0001
IL1β + COX2 1.94 (0.71–5.27) 0.058 IL1β + COX2 4.03 (0.89–18.23) < 0.0001 < 0.0001
IL1β + TNFα 1.37 (0.71–2.65) 0.212 IL1β + TNFα 3.27 (0.94–11.32) < 0.0001 < 0.0001
COX2 + TNFα 1.21 (0.79–1.85) 0.293 COX2 + TNFα 2.74 (1.07–7.04) < 0.0001 < 0.0001
IL-1β + COX-2 + TNFα 6.35 (0.40–101.55) 0.033 IL-1β + COX-2 + TNFα 17.37 (0.54–560.39) < 0.0001 < 0.0001
Baseline BML 2.43 (1.44–4.08) < 0.0001 Baseline BML     
Osteophytes MFC 1.42 (0.96–2.08) 0.102 Osteophytes MFC 2.82 (1.12–7.09) < 0.0001 < 0.0001
Osteophytes MTP 1.01 (0.71–1.45) 0.884 Osteophytes MTP 3.03 (1.20–7.68) < 0.0001 < 0.0001
Osteophytes LFC 1.80 (1.19–2.73) 0.006 Osteophytes LFC 3.82 (1.485–9.820) < 0.0001 < 0.0001
Osteophytes LTP 1.25 (0.86–1.81) 0.226 Osteophytes LTP 3.83 (1.452–10.107) < 0.0001 < 0.0001
Osteophytes MFC + MTP 1.78 (0.76–4.14) 0.212 Osteophytes MFC + MTP 4.72 (1.12–19.87) < 0.0001 < 0.0001
Osteophytes LFC + LTP 3.35 (1.35–8.30) 0.002 Osteophytes LFC + LTP 9.14 (1.98–42.32) < 0.0001 < 0.0001
ALL osteophytes 4.20 (0.60–29.65) 0.007 ALL osteophytes 12.10 (0.83–177.02) < 0.0001 < 0.0001
IL-1β + COX-2 + TNFα + osteophytes MFC + MTP 11.27 (0.27–467.4) 0.038 IL-1β + COX-2 + TNFα + osteophytes MFC + MTP 30.58 (0.37–2532.1) < 0.0001 < 0.0001
IL-1β + COX-2 + TNFα + osteophytes LFC + LTP 62.06 (1.15–3365.4) < 0.0001 IL-1β + COX-2 + TNFα + osteophytes LFC + LTP 232.9 (1.85–29,402.2) < 0.0001 < 0.0001
IL-1β + COX-2 + TNFα + ALL osteophytes 69.48 (0.40–12,199.8) < 0.0001 IL-1β + COX-2 + TNFα + ALL osteophytes 310.3 (0.67–142,727.2) < 0.0001 < 0.0001
ALL markers 310.26 (0.67–142,727.2) < 0.0001      NaN
  1. PBL peripheral blood leukocyte, BML bone marrow lesion, JSN joint space narrowing, COX-2 cyclooxygenase-2, IL-1β interleukin-1 beta, TNFα tumor necrosis factor alpha, 95% CI 95% confidence intervals. All comparisons are versus non-progressors (JSN ≤ 0 mm). Medial (MTP) and lateral (LTP) osteophytes in tibial plateau and medial (MFC) and lateral (LFC) femoral condyle. Total number of progressors (n = 66) and non-progressors (n = 63) in the combined cohort