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Table 6 The odds ratios (OR) comparing baseline inflammatory PBL inflammatory gene expression biomarkers and osteophytes with and without medial BML to predict 24-month fast radiographic knee OA progression in the combined NYU and OAI cohorts

From: The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis

Biomarkers

 

Biomarkers + baseline medial BML

Fast progressors (JSN > 0.5 mm) vs. non-progressors (JSN ≤ 0.0 mm)

Odds ratio

95% CI

Adjusted p value for model

Biomarkers + baseline medial BML

Odds ratio

95% CI

Adjusted p value for model

p value for increase

Age

1

(1.0–1.0)

0.769

Age

2.46

(1.32–4.6)

0.006

0.001

Sex

1

(1.0–1.0)

0.678

Sex

2.29

(1.24–4.23)

0.007

0.002

BMI

1

(1.0–1.0)

0.151

BMI

2.15

(1.17–3.96)

0.006

0.005

COX-2

3.56

(0.92–13.72)

0.019

COX-2

8.64

(1.36–54.84)

< 0.0001

< 0.0001

IL-1β

1.90

(0.56–6.41)

0.074

IL-1β

4.09

(0.753–22.230)

< 0.0001

< 0.0001

TNFα

1.12

(0.78–1.63)

0.696

TNFα

3.11

(1.19–8.14)

< 0.0001

< 0.0001

IL1β + COX2

1.94

(0.71–5.27)

0.058

IL1β + COX2

4.03

(0.89–18.23)

< 0.0001

< 0.0001

IL1β + TNFα

1.37

(0.71–2.65)

0.212

IL1β + TNFα

3.27

(0.94–11.32)

< 0.0001

< 0.0001

COX2 + TNFα

1.21

(0.79–1.85)

0.293

COX2 + TNFα

2.74

(1.07–7.04)

< 0.0001

< 0.0001

IL-1β + COX-2 + TNFα

6.35

(0.40–101.55)

0.033

IL-1β + COX-2 + TNFα

17.37

(0.54–560.39)

< 0.0001

< 0.0001

Baseline BML

2.43

(1.44–4.08)

< 0.0001

Baseline BML

    

Osteophytes MFC

1.42

(0.96–2.08)

0.102

Osteophytes MFC

2.82

(1.12–7.09)

< 0.0001

< 0.0001

Osteophytes MTP

1.01

(0.71–1.45)

0.884

Osteophytes MTP

3.03

(1.20–7.68)

< 0.0001

< 0.0001

Osteophytes LFC

1.80

(1.19–2.73)

0.006

Osteophytes LFC

3.82

(1.485–9.820)

< 0.0001

< 0.0001

Osteophytes LTP

1.25

(0.86–1.81)

0.226

Osteophytes LTP

3.83

(1.452–10.107)

< 0.0001

< 0.0001

Osteophytes MFC + MTP

1.78

(0.76–4.14)

0.212

Osteophytes MFC + MTP

4.72

(1.12–19.87)

< 0.0001

< 0.0001

Osteophytes LFC + LTP

3.35

(1.35–8.30)

0.002

Osteophytes LFC + LTP

9.14

(1.98–42.32)

< 0.0001

< 0.0001

ALL osteophytes

4.20

(0.60–29.65)

0.007

ALL osteophytes

12.10

(0.83–177.02)

< 0.0001

< 0.0001

IL-1β + COX-2 + TNFα + osteophytes MFC + MTP

11.27

(0.27–467.4)

0.038

IL-1β + COX-2 + TNFα + osteophytes MFC + MTP

30.58

(0.37–2532.1)

< 0.0001

< 0.0001

IL-1β + COX-2 + TNFα + osteophytes LFC + LTP

62.06

(1.15–3365.4)

< 0.0001

IL-1β + COX-2 + TNFα + osteophytes LFC + LTP

232.9

(1.85–29,402.2)

< 0.0001

< 0.0001

IL-1β + COX-2 + TNFα + ALL osteophytes

69.48

(0.40–12,199.8)

< 0.0001

IL-1β + COX-2 + TNFα + ALL osteophytes

310.3

(0.67–142,727.2)

< 0.0001

< 0.0001

ALL markers

310.26

(0.67–142,727.2)

< 0.0001

    

NaN

  1. PBL peripheral blood leukocyte, BML bone marrow lesion, JSN joint space narrowing, COX-2 cyclooxygenase-2, IL-1β interleukin-1 beta, TNFα tumor necrosis factor alpha, 95% CI 95% confidence intervals. All comparisons are versus non-progressors (JSN ≤ 0 mm). Medial (MTP) and lateral (LTP) osteophytes in tibial plateau and medial (MFC) and lateral (LFC) femoral condyle. Total number of progressors (n = 66) and non-progressors (n = 63) in the combined cohort
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Arthritis Research & Therapy

ISSN: 1478-6362

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