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Table 2 Total effect of E-DII on incident ROA and incident SxOA

From: Inflammatory potential of diet and risk of incident knee osteoarthritis: a prospective cohort study

E-DII in quartile

Q1

Q2

Q3

Q4

P for trend*

ROA

 Median

− 3.9

− 2.7

− 1.3

0.9

 

 ROA knees#

48/896

53/892

66/892

65/892

 

 Model 1†

1.00 (ref)

1.12 (0.75, 1.68)

1.48 (1.00, 2.18)

1.43 (0.96, 2.11)

0.049

 Model 2‡

1.00 (ref)

1.27 (0.84, 1.94)

1.53 (1.01, 2.32)

1.73 (1.15, 2.62)

0.007

SxOA

 Median

− 3.9

− 2.7

− 1.4

0.8

 

 SxOA knees#

218/1472

237/1470

260/1470

263/1468

 

 Model 1†

1.00 (ref)

1.12 (0.92, 1.37)

1.28 (1.05, 1.56)

1.37 (1.12, 1.68)

0.001

 Model 2‡

1.00 (ref)

1.13 (0.92, 1.40)

1.27 (1.04, 1.56)

1.43 (1.16, 1.76)

0.001

  1. E-DII energy-adjusted dietary inflammatory index, BMI body mass index, OA osteoarthritis, PASE Physical Activity in the Elderly Scale, ROA radiographic knee osteoarthritis, SxOA, symptomatic knee osteoarthritis
  2. *Test for trend based on the variable containing the median value for each quartile
  3. #Number of OA affected/total number of knees in each quartile of the dietary inflammatory index
  4. †Model 1 adjusted for age (years), sex (men vs women), race (white vs non-white), and total energy intake (kcal/day)
  5. ‡Model 2 further adjusted for education (< college vs ≥ college), yearly income level (< 50,000 US$ vs ≥ 50,000 US$), tobacco use (non-smoker vs smoker), and physical activity (PASE, continuous)