Fig. 2
From: PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling
Overexpression of PRMT5 contributes to cartilage degeneration. a Expression levels of MMP-3, MMP-13, ADAMTs5, Sox9, Collagen II, and PRMT5 in human chondrocytes from the control, Ad-NC, and Ad-PRMT5 groups were determined by western blotting. b Histogram showing the relative protein expression levels of PRMT5, MMP-3, MMP-13, ADAMTs5, Sox9, and Collagen II in human chondrocytes. c Changes in MMP-3, MMP-13, PRMT5, ADAMTs5, Sox9, and Collagen II gene expression levels in human chondrocytes transduced with Ad-PRMT5. Data of independent experiments (n = 3) were presented as mean ± SD and analyzed using the one-way analysis of variance with the SNK post hoc test. *P < 0.05 vs. the Ad-NC group