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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling

Fig. 3

Inhibition of PRMT5 attenuates IL-1β-stimulated chondrocyte catabolism. a Representative western blots showing the expression levels of MMP-3, MMP-13, Sox9, and Collagen II in IL-1β-stimulated human chondrocytes in response to EPZ. b Histogram showing the relative protein expression levels of MMP-3, MMP-13, Sox9, and Collagen II in human chondrocytes. c Alcian blue staining of micromass cultures incubated in the absence of IL-1β, with or without EPZ. d Alcian blue-stained cultures were extracted using 6 M guanidine hydrochloride; the absorbance of the supernatant was measured at 600 nm. Data of independent experiments (n = 3) were presented as mean ± SD and analyzed using the one-way analysis of variance with the SNK post hoc test. *P < 0.05 vs. the IL-1β group. #P < 0.05 vs. the con group

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