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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling

Fig. 4

EPZ reduces the progression of experimental OA. a Hematoxylin and eosin and safranin O-fast green staining of the coronal sections from the knee joint cartilage of sham, DMM, and DMM+EPZ mice. Scale bar = 100 μm. b Histopathological examination using the Osteoarthritis Research Society International criteria to assess cartilage degeneration. c MMP-3, MMP-13, PRMT5, p-p38, and p-p65 expression, as detected by immunohistochemical staining. Data were presented as mean ± SD from 10 samples. Data were analyzed using the one-way analysis of variance with the SNK post hoc test. *P < 0.05 vs. the DMM group. #P < 0.05 vs. the sham group

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